ID A0A2Y9DHI8_TRIMA Unreviewed; 683 AA.
AC A0A2Y9DHI8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Regulator of G-protein signaling 9 {ECO:0000256|ARBA:ARBA00034540};
GN Name=LOC101347241 {ECO:0000313|RefSeq:XP_004374251.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374251.1};
RN [1] {ECO:0000313|RefSeq:XP_004374251.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_004374251.1; XM_004374194.2.
DR AlphaFoldDB; A0A2Y9DHI8; -.
DR STRING; 127582.A0A2Y9DHI8; -.
DR GeneID; 101347241; -.
DR KEGG; tmu:101347241; -.
DR InParanoid; A0A2Y9DHI8; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08739; RGS_RGS9; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR047077; RGS9_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF1; REGULATOR OF G-PROTEIN SIGNALING 9; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 30..105
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 299..414
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 490..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 77485 MW; E73D68FA9B5E8BE5 CRC64;
MTIRHQGQQY RPRMAFLQKI EGLVKDMQSP ETGVRMQNQR VLVTNVPHAM TGSDVLQWII
DRLWISNMEA QNLGNFIVKY GYIYPLQDPK NLVLKPDGSL YRFQTPYFWP TQQWPAEDTD
YAIYLAKRNI KKKGILEEYE KENYNFLNKK INYKWDFVIM QAKEQYRAGK ERNKADRYAL
DCQEKAYWLV HRCPPGVNNV LDYGLNRVTN PDEVKKQTIT AVKKEIMYYQ QALMRSTVKS
SVSLGGIVKY SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEIPTK MRVERWAFNF
SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI YKLFLAPGAR
RWINIDGKTM DITVKGLRHP HRYVLDAAQT HIYMLMKKDS YARYLKSPIY KEMLAKAIEP
QETTKKSSSL PFMRRHLRSS PSPVILRQLE EEARAREAAN TVDITQRLQH STPSPHLAVY
AGTCVPPSPS SPFSSSCRSP RRPFPSPGRF RRPSSTICPS PIRVALGSSP GLEQEGEASG
SSARHGPSVA KGSEASMDSE LSSGCPRPHA QPRAPPKAGV ALSFSRFLRR GCLTSPVFAR
LSPKCPPVPH GKVQPLGDGG QQLPRLRPKK VANFFQIKMD VPMGSGTCLM DSEKDGAAGE
SNDRAMEKEV ICPWESLAEG KAG
//
