ID   A0A2Y9DHP6_TRIMA        Unreviewed;       854 AA.
AC   A0A2Y9DHP6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Protein PML isoform X1 {ECO:0000313|RefSeq:XP_004374794.1};
GN   Name=LOC101356208 {ECO:0000313|RefSeq:XP_004374794.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374794.1};
RN   [1] {ECO:0000313|RefSeq:XP_004374794.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_004374794.1; XM_004374737.3.
DR   AlphaFoldDB; A0A2Y9DHP6; -.
DR   STRING; 127582.A0A2Y9DHP6; -.
DR   GeneID; 101356208; -.
DR   KEGG; tmu:101356208; -.
DR   InParanoid; A0A2Y9DHP6; -.
DR   OrthoDB; 5352396at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd19804; Bbox1_TRIM19_C-V; 1.
DR   CDD; cd19770; Bbox2_TRIM19_C-V; 1.
DR   CDD; cd16579; RING-HC_PML_C-V; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR021978; PML-like_CC.
DR   InterPro; IPR047153; TRIM45/56/19.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR   PANTHER; PTHR25462:SF301; PROTEIN PML; 1.
DR   Pfam; PF12126; DUF3583; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   SMART; SM00336; BBOX; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50119; ZF_BBOX; 2.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00024}.
FT   DOMAIN          35..70
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          102..144
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          162..211
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..481
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   854 AA;  95087 MW;  F66D44CA344A4F28 CRC64;
     MPPPESPFED HQPSPSPSPS PSPSPTEEEF QFLCCQCCKA EAKCPKLLPC LHTLCSGCLE
     AAGVHCPICQ APRSPGADAQ ALDNVFFESL QRRLSMYREI VSLHAACTRC KEPADFWCFE
     CEQLICTKCF EAHQWFVKHE ARPLASLRSQ SVHEFLDGSR KSNNIFCSNS KHHTPELTSI
     YCRGCSKPLC CSCALLDTGH SELKCDIRAE IQQRQEELDT MTQALQEQDG VFGAAHAQMR
     SAIGQLDRAR ADTEELIRAR VRQVVAHVQM QEHKLIQSLK ARYQSESEEM TRRLSRLDAV
     LQRIRTGGAL VQRMKRYASD QEVLDMHSFL REALHRLRQE EPQSLQAPVP TNSFDEFKVR
     LRDLVSCITQ GTDAALPRRA SPEAASTPRN SFDVDLPEEA QRAQAQVMGL SEAQPMAVVQ
     QEPGAHPVPM YAFSIKDPSY REEAPSPLTP QKRKSCQTEG PRKIIKLESE EEKEERLARS
     SPEQPRPSTS KAVSPPHLDE PPSLGSPDTG NKVLLLNNNH VTSEPGEEAE ERVVVISSSE
     DSDAENSSSR ELDDSSSESS DLQLEGPSTL RVLDESLADP QAEDRPLVFF DLRIDNETQK
     ISQLAAVNRE SKFRVLIQPK AFFSIYSKAV SLEVGLRHFL RFLGSMRRPI LACYKLWGPS
     LPYFFQALED MNSLWEFQEA ISGFLATLPL IRECVPGASS FKLKSLAKTY LARNVNDHSA
     LASVLAMRDL CHLLEVFPGP SLAQHVYSFS DLQCFASLQP LVRAAVLPRA NARLLALHNV
     SFVELLAAHR CDPKWGLKKY SRYLSLQAAP ALPAQPALDL QALSAYFATL LAQGEGISAP
     PSGHSLVERA SQQN
//