ID A0A2Y9DHY5_TRIMA Unreviewed; 964 AA.
AC A0A2Y9DHY5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Thrombospondin-4 {ECO:0000313|RefSeq:XP_004374519.1};
GN Name=LOC101352874 {ECO:0000313|RefSeq:XP_004374519.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374519.1};
RN [1] {ECO:0000313|RefSeq:XP_004374519.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_004374519.1; XM_004374462.1.
DR AlphaFoldDB; A0A2Y9DHY5; -.
DR STRING; 127582.A0A2Y9DHY5; -.
DR GeneID; 101352874; -.
DR KEGG; tmu:101352874; -.
DR InParanoid; A0A2Y9DHY5; -.
DR OrthoDB; 5345349at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd16080; TSP-4cc; 1.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR024665; TSP/COMP_coiled-coil.
DR InterPro; IPR046970; TSP/COMP_coiled-coil_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF92; THROMBOSPONDIN-4; 1.
DR Pfam; PF11598; COMP; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02412; TSP_3; 5.
DR Pfam; PF05735; TSP_C; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF58006; Assembly domain of cartilage oligomeric matrix protein; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51234; TSP3; 3.
DR PROSITE; PS51236; TSP_CTER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..964
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016067849"
FT DOMAIN 329..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 423..465
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 499..534
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 558..593
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 695..730
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 734..948
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 271..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 106239 MW; 5AD25A27EAF9019A CRC64;
MLARHGAAFL LLHLVLQPWL GADAQATPQV FDLLPSSSQR LNPGILQPIL TDPTLNEIYV
ISTFKLQTKS TATIFGLYSS TDNSKYFEFT VMGRLNKAIL RYLKTDGKIH LVVFNNLQLA
DGRRHRILLR LTNWQRGAGS VELYLDCTQV DSIHNLPRAF SGLSQSPKSI ELRTFQRKAQ
DFLEELKLVV RGSLIQVASL QDCFLQQSEP LATISTGDFN RQFLGQMTQL NHLLAEVKDL
LRQQVKETSF LRNTIAECQA CGPLSVQSST TNTLVPPAPP APPTSPTPPV RRCDPNSCFR
GVRCTDTRDG FQCGPCPVGY TGNGITCSDI DECKYHPCYP GVRCVNLAPG FRCDACPVGF
TGSMVQGVGI TFANLNKQVC TDIDECQNGA CVLNSICINT WGSYRCGPCK SGYAGDQTRG
CKAERSCKNP ELNPCSVNAQ CIEERQGDVT CVCGVGWAGD GYICGKDVDI DSYPDEELPC
SARNCKKDNC KYVPNSGQED ADGDGIGDTC DEDADGDGIL NEQDNCVLTH NVDQRNSDKD
IFGDACDNCR TVLNNDQKDT DGDGKGDACD DDMDGDGIKN VLDNCPKVPN HDQQDKDNDG
VGDACDSCPD ISNPNQSDVD NDLVGDSCDT NQDSDGDGHQ DSTDNCPTVI NSAQLDTDKD
GIGDECDDDD DNDGIPDLVP PGPDNCRLVP NPAQEDSNSD GVGDVCEMDF DQDQVIDRID
VCPENAEVTL TDFRAYQTVV LDPEGDAQID PNWVVLNQGM EIVQTMNSDP GLAVGYTAFN
GVDFEGTFHV NTQTDDDYAG FIFGYQDSSS FYVVMWKQTE QTYWQATPFR AVAEPGIQLK
AVKSKTGPGE HLRNSLWHTG DTSDQVRLLW KDFRNVGWKD KVSYRWFLQH RPQVGYIRVR
FYEGSELVAD SGVTVDTTMR GGRLGVFCFS QENIIWSNLK YRCNDTIPED FQEFQTHNFD
QLDN
//
