ID A0A2Y9DIL6_TRIMA Unreviewed; 655 AA.
AC A0A2Y9DIL6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Actin-binding LIM protein 1 isoform X1 {ECO:0000313|RefSeq:XP_004374922.1};
GN Name=LOC101347995 {ECO:0000313|RefSeq:XP_004374922.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004374922.1};
RN [1] {ECO:0000313|RefSeq:XP_004374922.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_004374922.1; XM_004374865.2.
DR AlphaFoldDB; A0A2Y9DIL6; -.
DR GeneID; 101347995; -.
DR KEGG; tmu:101347995; -.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd09327; LIM1_abLIM; 1.
DR CDD; cd09328; LIM2_abLIM; 1.
DR CDD; cd09329; LIM3_abLIM; 1.
DR CDD; cd09330; LIM4_abLIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR032402; AbLIM_anchor.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24213; ACTIN-BINDING LIM PROTEIN; 1.
DR PANTHER; PTHR24213:SF18; ACTIN-BINDING LIM PROTEIN 1; 1.
DR Pfam; PF16182; AbLIM_anchor; 2.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF02209; VHP; 1.
DR SMART; SM00132; LIM; 4.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 21..80
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 82..140
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 148..207
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 587..655
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 263..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 73993 MW; 5ECC52A176145F1C CRC64;
MVKEKVAPPQ DAAPPSEKPV IHCHKCGEPC KGEVLRVQTR HFHIKCFTCK VCGCDLAQGG
FFIKNGEYLC TLDYQRMYGT CCHGCGEFVE GEVVTALGKT YHPNCFACTI CKRPFPPGDR
VTFNGRDCLC QLCAQPMSSS PKEATCSSNC AGCGRDIKNG QALLALDKQW HLGCFKCKSC
GKVLTGEYIS KDGAPYCEKD YQGLFGVKCE ACHQFITGKV LEAGDKHYHP SCARCSRCNQ
MFTEGEEMYL QGSTVWHPDC KQSTKTEEKL RPTRTSSESI YSRPGSSIPG SPGHTIYAKV
DNEILDYKDL AAIPKVKAIY DIERPDLITY EPFYTSGYDD KQERQSLGES PRTLSPTPSA
EGYQDVRDRM IHRSTSQGSI NSPVYSRHSY TPTTSRSPQH FHRPGNEPSS GRNSPLPYRP
DSRPLTPTYA QAPKHFHVPD QGINIYRKPP IYKQHGTDMR RRSSGREEDE EELLRRRQLQ
EEQLMKLNSG LGQLILKEEM EKESRERASL SASRYDSPIN SASHAPSSKT SSLPGYGKNG
LHRPVSTEFA QYNSYGDVSG GVRDYQTLPD GHMPGMRMDR GVSMPNMLEP KIFPYEMLMV
TNRGRNKILR DVDRTRLERH LSPEVFREIF GMSIQEFDRL PLWRRNDMKK KAKLF
//
