ID A0A2Y9DIX9_TRIMA Unreviewed; 2172 AA.
AC A0A2Y9DIX9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bromodomain adjacent to zinc finger domain protein 2B isoform X8 {ECO:0000313|RefSeq:XP_004375469.1};
GN Name=LOC101359017 {ECO:0000313|RefSeq:XP_004375469.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004375469.1};
RN [1] {ECO:0000313|RefSeq:XP_004375469.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR RefSeq; XP_004375469.1; XM_004375412.3.
DR GeneID; 101359017; -.
DR KEGG; tmu:101359017; -.
DR OrthoDB; 2912910at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 740..811
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1088..1153
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1935..1985
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2081..2151
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1669..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1997..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..661
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1321
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2172 AA; 240920 MW; 96F720D2E9EC3266 CRC64;
MESGERLSSS TASSTTPTSS STPPVASAVS KGGLSTGVAS LSSTINPCGH LFRAAGDQPF
NLSTVSSAFP MVSPPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PGAEWWRTAD
VPTRTGATFF PPLLGIPPLF APPAQNHDSS SFHSRTSGKS NRNGPEKGVN GSINGNSTSS
VSGISTSVLS TTASGSTGQT KTISSGGGNR KCNQEQSKNQ PLDPRADKIK DKKPRKKTME
SSSNSDSDSG TSSDTSSEGI SSSDSDDLEE DEEEEDQSLE ESEDDDSDSE SEAQHKSNNQ
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LVSESQTHSS FQSQQKQPQV LSQQLPFIFQ
SSQAKEESVN KHTSVIQSTG LVSNVKPLSL VNQAKKETYM KLIVPSPDVL KAGNKNTSEE
SSPLTSELRS KREQYKQTFP AQLKKQESSR SLKKVISALS NPKATSSSPA HPKQTLENNH
PNPFLTNALL GNHQPNGVIQ SVIQEAPLAL TTKTKIQSRI NENIATASST PFSSPVNLST
SGRRTPGNQT PVMPSASPIL HSQGKEKAVS NNVNTLQTQH HPHPAKSLVE QFRGTDSDIP
SSKDSEDSNE DEEEDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED DDDDKDQDES
DSDTEGEKTS MKLNKTASSV KSPSMSLSAH STPRNLHIAK APGSAPAALC SESQSPAFLG
TPSSTLTSSP HSGTSKRRRV TDERELRIPL EYGWQRETRI RNFGGRLQGE VAYYAPCGKK
LRQYPEVIKY LSRNGIMDIS RDNFSFSAKI RVGDFYEARD GPQGMQWCLL KEEDVIPRIR
AMEGRRGRPP NPDRQRAREE SRMRRRKGRP PNVGNAEFVD NTDAKLLRKL QAQEIARQAA
QIKLLRKLQK QEQARVAKEA KKQQAIMAAE EKRKQKEQIK IMKQQEKIKR IQQIRMEKEL
RAQQILEAKK KKKEEAANAK LLEAEKRIKE KEMRRQQAVL LKHQERERRR QHMMLMKAME
ARKKAEEKER LKQEKRDEKR LNKERKLEQR RLELEMAKEL KKPNEDMCLA DQKPLPELPR
IPGLVLSGST FSDCLMVVQF LRNFGKVLGF DVNIDVPNLS VLQEGLLNIG DSMGEVQDLL
VRLLSAAVCD PGLITGYKAK TALGEHLLNV GVNRDNVSEI LQIFMEAHCG QTELTESLKT
KAFQAHTPEQ KASVLAFLIN ELACSKSVVS EIDKNIDYMS NLRRDKWVVE GKLRKLRIIH
AKKTGKRDTS GGTDLGEEQH PLGTPTPGRK RRRKGGDSDY DDDDDDDSDE QADEDDEDEE
DKEDKKGKKA DVCEDEDEGD QAASVEELEK QIEKLSKQQS QYRRKLFDAS HSLRSMMFGQ
DRYRRRYWIL PQCGGIFVEG MESGEGLEEI AKEREKLKKA ESIQIKEEMF ETSGDILNCL
NTDHCEQKED LKEKDNTNLF LQKPGSFSKL SKLLEVAKMP PESDSMTPKP NGSANGCTMS
YQNSGKHSLG SLQSTATQSN VEKTDSNNLF SPGSGGPGKF YSPLPSDQLL KTLTEKNRQW
FSLLPRTPCD DTSLTHADVS AASLVAPQSQ PPPKSPSPAP APLLGSSSSQ NPIGLNPFAL
SPLQIKSGVS MMGLQFCGWP TGVLTSNIPF TSSPLPNLGS GLGLSEGNGN SFLTPNAASS
KSESPVPQNE KVSSTQPAAI EVVKPVDFLS PKPIPEEMQF GWWRIIDPED LKALLKVLHL
RGIREKALQK QIQKHLDYIT QACIKNKDVA IIELNENEEN QVTRDIVENW SVEEQAMEMD
LSILQQVEDL ERRVASASLQ VKGWMCPEPA SEREDLVYFE HKSFTKLCKE HDGEFTGKEE
SSAHALERQS DNPLDIAVTR LADLERNIER RIEEDIAPGL RVWRRALSEA RSAAQVALCI
QQLQKSIAWE KSIMKVYCQI CRKGDNEELL LLCDGCDKGC HTYCHRPKIT TIPDGDWFCP
ACIAKASGQT LKIKKLHVKG KKANEPKKGK KVPLAGDTED EDSASTSSSL KRGNKDLKKR
KMEENTSINL SKQDSFTSVK KPKRDDSKDL ALCSMILTEM ETHEDAWPFL LPVNLKLVPG
YKKVIKKPMD FSTIREKLSS GQYPNLETFA VDVRLVFDNC ETFNEDDSDI GRAGHSMRKY
FEKKWTDTFK VS
//
