ID A0A2Y9DJB1_TRIMA Unreviewed; 321 AA.
AC A0A2Y9DJB1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Torsin {ECO:0000256|PIRNR:PIRNR038079};
GN Name=LOC101346652 {ECO:0000313|RefSeq:XP_004375749.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004375749.1};
RN [1] {ECO:0000313|RefSeq:XP_004375749.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319, ECO:0000256|PIRNR:PIRNR038079}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235, ECO:0000256|PIRNR:PIRNR038079}.
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DR RefSeq; XP_004375749.1; XM_004375692.2.
DR AlphaFoldDB; A0A2Y9DJB1; -.
DR STRING; 127582.A0A2Y9DJB1; -.
DR GeneID; 101346652; -.
DR KEGG; tmu:101346652; -.
DR InParanoid; A0A2Y9DJB1; -.
DR OrthoDB; 5087at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR InterPro; IPR017378; Torsin_1/2.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF4; TORSIN-2A; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR PIRSF; PIRSF038079; Torsin_2A; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR038079};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..321
FT /note="Torsin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016052165"
FT DOMAIN 85..227
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 93..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR038079-1"
SQ SEQUENCE 321 AA; 36207 MW; 30195976199E61DC CRC64;
MAAATRDCWP WGSFLGLLGL VSAAAAAWDL ASLRCNFGDF CECDFRPDFQ GLECDLAQHL
AGQHLAKALV VKALKAFVHD PAPKKPLVLS LHGWTGTGKS YVSSLLAHYL FRGGLRSPHV
HHFSPVIHFP HPSHIERYKK DLKSWIQGNL TACSRSLFLF DEMDKLPPGL MEVLRPFLGS
SWVVYGTNYR KAIFIFISNT GGEQINQVVL EAWRSRRDRE EIRLQELEPA ISRAVLDNPQ
HGFWRSGIVE EHLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPRDEVVQA MLESTTFFPE
DEQLFSSNGC KTVASRIAFF L
//
