ID A0A2Y9DKY3_TRIMA Unreviewed; 448 AA.
AC A0A2Y9DKY3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=LOC101341737 {ECO:0000313|RefSeq:XP_004376445.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004376445.1};
RN [1] {ECO:0000313|RefSeq:XP_004376445.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR RefSeq; XP_004376445.1; XM_004376388.2.
DR STRING; 127582.A0A2Y9DKY3; -.
DR GeneID; 101341737; -.
DR KEGG; tmu:101341737; -.
DR InParanoid; A0A2Y9DKY3; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19338; Wnt_Wnt6; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009143; Wnt6.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF72; PROTEIN WNT-6; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01845; WNT6PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT REGION 223..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 48818 MW; 1888FFBD37DB32A4 CRC64;
MVVMGDWPLL LNTRTTCPSA PLGTSGEGAL SWLQERGLEE QGLPPAASSL HREQYAHTGS
CWPRSRFRDS GKTPLGGPVR WQIEDDPRSR LGILHPLILV CPGQXGGVWW AVGSPLVMDP
ISICRKARRV AGRQAELCQA EPEVVAELAR GARLGVRECQ FQFRFRRWNC SSHSKAFGRI
LQQDIRETAF VFAITAAGAS HAVTQACSTG ELLQCGCQAP RARAPPRPPG LPGTPGPPVP
AGSPEASATW EWGGCGDDVD FGDEKSRLFM DAQHKRGRGD IRALVQLHNN EAGRLAVRSH
TRTECKCHGL SGSCALRTCW QKLPPFREVG ARLLERFHGA SRVMGTNDGK ALLPAVRTLK
PPGRADLLYA ADSPDFCAPN RRTGSPGTRG RACNSSAPDL SGCDLLCCGR GHRQESVQLE
ENCLCRFHWC CVVQCHRCSV RKELSLCL
//
