ID   A0A2Y9DL01_TRIMA        Unreviewed;      2037 AA.
AC   A0A2Y9DL01;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Ral GTPase-activating protein subunit alpha-1 isoform X6 {ECO:0000313|RefSeq:XP_004376565.1};
GN   Name=LOC101353910 {ECO:0000313|RefSeq:XP_004376565.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004376565.1};
RN   [1] {ECO:0000313|RefSeq:XP_004376565.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004376565.1; XM_004376508.2.
DR   GeneID; 101353910; -.
DR   OrthoDB; 21929at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR046859; RGPA/RALGAPB_N.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF20412; RALGAPB_N; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          1797..2005
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          343..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          812..833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          982..1009
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..747
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        894..910
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2037 AA;  229776 MW;  CE2E080D61C5C97E CRC64;
     MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
     NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
     SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEHGPRTL DNLINPPLNL
     QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQEKGFSFL
     FLHFKKYYLP YIFPNICKEN SLYHPVLDIP QMRPKPHYVM VKKDAETNEA IYCTKEPFIK
     ARVIVIRWLV SFWLEPKPHA GPHIPGMEGE VLPKNIQRAA ASLVSREESK NDNADKADRT
     TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
     LPICEAAAMR RVVKVYQEWI QQEEKPLFMQ EPEEIVISSS DLPCIENVTD HDISVEEGEK
     REEENGTVTA DHARNSSWAK NDTYQDALHN ASEEATEQNI RAGTQAVLQV FIINSSNIFL
     LEPANEIKSL LDEHTDMCKR ILNIYRFMVV QVSMDKKTWE QMLLVLLRVT ESVLKMPSQA
     FLQFQGKKNM TLASRLAGPL FQTLIVAWIK ANLNVYISRE LWDDLLSVLS SLTYWEELAT
     EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW
     SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVDIDDA QILPRPTRVR HFSQSEDTGN
     EVFGALNEEQ PLPRSSSTSD ILEPFTVERA KANKEDMSPK LPPLNSDIGS SSANVPDLMD
     EFIAERLRSG NASTMTRRGS SPGSLEIPKD LPDSLNKQSQ MRPIDDPGVP SEWTSPASAG
     SSDLISSDSH SDSFSAFQYD GRKFENFGFG ADTGIATSAD VDSGSGHHQS AEEQEVASLT
     TLHMDSETSS LNQQAFSAEV ATVTGSESAS PVHSALGSRS QTPSPSTLNI DHMEQKDLQL
     DEKLHHSVLQ TPDDLEISEF PSECCSVMAG GTLTGWHADV ATVMWRRMLG ILGDVNAIMD
     PEIHAQVFDY LCELWQNLAK IRDNLGISTD NLTSPSPPVL IPPLRILTPW LFKATMLTDK
     YKQGKLHAYK LICNTMKRRQ DVSPNRDFLT HFYNIMHCGL LHIDQDIVNT IIKHCSPQFF
     SLGLPGATML IMDFIVAAGR VASSAFLNAP RVEAQVLLGS LVCFPNLYCE LSALHPNIPD
     IAVSQFTDVK ELIIKTVLSS ARDEPSGPAR CVALCSLGIW ICEELVHESH HPQIKEALNV
     ICVSLKFTNK TVAYVACNML HMLVHYVPRL QIYQPDSPLK IIQILIATIT HLLPSTEASS
     YEMDKRLVVS LLLCLLDWIM ALPLKTLLQP IHTTGTENDK TEKSVLNCIY KVLHGCVYGA
     QCFSNPKYFP ISLSDLASVD YDPFMHLESL KEPEPLHSPD SERSSKLQPV TEVKTQMQQG
     LISVAARTVI THLVNHLGHY PMSGGPAMLT SQVCENHDNH YSESPELSPE LFESPNIQFF
     VLNNTTLVSC IQIRSEESMP GGGLSAGLAS ANSNVRIIVR DLSGKYSWDS AILYGPPPVS
     GLSEPTSFIL SLSHHEKPEE PPTSNECLED TTEKDGVSLQ FKGRFRETVP TWDTIRDEED
     VLDELLQYLG VTSPECLQRT GISLNIPAPQ PVCISEKQEN DVINAILKQY TEEKEFVEKH
     FNDLNMKAVE QDEPTPQKPQ SAFYYCRLLL SILGMNSWDK RRSFHLLKKN EKLLRELRNL
     DSRQCRETHK IAVFYVAEGQ EDKHSILTNR GGSQAYEDFV AGLGWEVNLT NHCGFMGGLQ
     KNKSTGLTTP YFATSTVEVI FHVSTRMPSD SDDSLTKKLR HLGNDEVHIV WSEHTRDYRR
     GIIPTEFGDV LIVIYPMKNH MFSIQIMKKP EVPFFGPLFD GAIVNGKVLP IMVRATAINA
     SRALKSLIPL YQNFYEERAR YLQTIVQHHL EPTTFEDFAA QVFSPAPYHH LPSDADH
//