ID   A0A2Y9DLA0_TRIMA        Unreviewed;       971 AA.
AC   A0A2Y9DLA0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Protocadherin-8 isoform X2 {ECO:0000313|RefSeq:XP_004376682.1};
GN   Name=LOC101345794 {ECO:0000313|RefSeq:XP_004376682.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004376682.1};
RN   [1] {ECO:0000313|RefSeq:XP_004376682.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_004376682.1; XM_004376625.1.
DR   AlphaFoldDB; A0A2Y9DLA0; -.
DR   GeneID; 101345794; -.
DR   OrthoDB; 4259465at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF46; PROTOCADHERIN-8; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..971
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016182546"
FT   TRANSMEM        748..769
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          28..135
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          136..245
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          247..354
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          391..495
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          496..607
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          613..718
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          710..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          871..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..971
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        810..830
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   971 AA;  103224 MW;  70C354B7BF4C5059 CRC64;
     MSPGKRGGSP CLFLLQLCSL CWVLSVAQSK TVRYSTFEED APGTVIGILA EDLHMKVSGD
     TSFRLMKQFN SSLIRVREGD GQLTVGDAGL DRERLCGRAP QCVLAFDVVS FSQEQFRLVH
     VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGGNGLQ SVHLAEPHSP
     FRVELQTRAD GAQCADLVLL QELDRETQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND
     HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFSFGARTP PEARRLFRLD
     PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDISITPLA
     APGAPAASPF ATAAAALGGS DATSLGGSGA PEAAATSLVP EGAARESLVA LVSTSDRDSG
     ANGQVRCALY GHEHFRLQPA YAGSYLVVTA ASLDRERIAE YNLTLVAEDR GMPPLRTVRP
     YTVRVGDEND NAPLFTRPVY DVSVRENNPP GAYLATVAAR DPDLGRNGQV TYRLLEAEVG
     RAGGAVSTYV SVDPATGAIY ALRSFDYEAL RQLDVRIQAS DGGSPQLSSS ALVQVRVLDQ
     NDHAPVLVHP APANGSLEVA VLGRTARDSA VARVQARDAD DGANGELAFD LLQQEPREAF
     AIGRRTGEIV LTGDLSQELP GRVFRALLVV SDGGRPPLST SAAVSFVVTA GGERGPEGPG
     SAGGTERSRP PGSRLGASGP ALQWDTPLIV IIVLAGSCTL LLAAIIAIAT TCNRRKEEPY
     VASPGFGKEP APPVAVWKGH SFNTISGREA EKFSGKDSGK GDSDFNDSDS DISGDALKKD
     LINHMQSGLW ACTAECKILG HSDRCWSPSC GGPNAPPPPH PPAQMSTFCK STSLPRDPLR
     RDNYYQAQLP KTVGLQSVYE KVLHRDYDRT VTLLSPPRPG RLPDLQEISV PLYQSPPGRY
     LSPKKGANEN V
//