ID   A0A2Y9DMP5_TRIMA        Unreviewed;       758 AA.
AC   A0A2Y9DMP5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|RefSeq:XP_004377383.1};
GN   Name=LOC101347000 {ECO:0000313|RefSeq:XP_004377383.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004377383.1};
RN   [1] {ECO:0000313|RefSeq:XP_004377383.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   RefSeq; XP_004377383.1; XM_004377326.2.
DR   AlphaFoldDB; A0A2Y9DMP5; -.
DR   STRING; 127582.A0A2Y9DMP5; -.
DR   GeneID; 101347000; -.
DR   KEGG; tmu:101347000; -.
DR   InParanoid; A0A2Y9DMP5; -.
DR   OrthoDB; 5475669at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03483; MutL_Trans_MLH1; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          216..335
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   REGION          401..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..432
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..489
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  84584 MW;  EC2EB76B285EEDCC CRC64;
     MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTSIQVV VKEGGLKLIQ
     IQDNGTGIRK EDLDIVCERF TTSKLKSFED LASISTYGFR GEALASISHV AHVTITTKTA
     DGKCAFRASY ADGKLKAPPK PCAGNQGTQI TVEDLFYNIA TRRKALKNPS EEYGKIVEVV
     GRYSIHNSGI SFSVKKQGET VADVRTLPNA TTVDNIRSIF GNAVSRELIE VGCEDKTLAF
     KMNGYISNAN YSVKKCIFLL FINHRLVESA SLRKAIETVY AAYLPKNTHP FLYLSLEISP
     QNVDVNVHPT KHEVHFLHED SILERVQQHI ESKLLGSNSS RTYFTQTLLP GLAGPSGEVV
     KSTIGMTSSS TSKSGDKVYA HQMVRTDSRE QKLDAFLQPV SKAVSSQPQA LVPEDSRDGS
     SGRTRQQDEE MLELPAPAEV VAKNQGFEEE ATKGPSETTE KRGPTLSPDV PRKRPREDSD
     VEMVEDESPK EITAACAPRR RIINLTSVLN LQEEINEQGH EALREMLHNH SFVGCVNPQW
     ALAQYQTKLY LLNTTKLSEE LFYQILIYDF ANFGVLRLSE PAPLFDLAML ALDSPESGWT
     EDDGPKEGLA EYIVEFLKKK AEMLADYFSL EIDEEGNLIG LPLLIDNYVP PLEGLPIFIL
     RLATEVNWDE EKDCFESLSK ECALFYSIRQ QYVCEGSTLS SQQSEEPGSA PNPWKWTVEH
     IVYKAFRSHL LPPKRFTEDG NILQLANLPD LYKVFERC
//