ID A0A2Y9DMS7_TRIMA Unreviewed; 410 AA.
AC A0A2Y9DMS7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Beta-chimaerin isoform X1 {ECO:0000313|RefSeq:XP_004377551.2};
GN Name=LOC101346826 {ECO:0000313|RefSeq:XP_004377551.2};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004377551.2};
RN [1] {ECO:0000313|RefSeq:XP_004377551.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004377551.2; XM_004377494.2.
DR AlphaFoldDB; A0A2Y9DMS7; -.
DR STRING; 127582.A0A2Y9DMS7; -.
DR KEGG; tmu:101346826; -.
DR InParanoid; A0A2Y9DMS7; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035840; Chimaerin_SH2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075:SF4; BETA-CHIMAERIN; 1.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 59..127
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 209..410
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 214..246
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 47222 MW; 9E89B47A415A2AB9 CRC64;
MAASSNSSLS GSSVSSDAEE YQPPIWKSYL YQLQQEAPRP KRIICPREVE NRPKYYGREF
HGIISREKAD ELLGGVEGAY ILRESQRQPG CYTLALRFGN QTLNYRLFYD GKHFVGEKRF
ESIHDLVTDG LITLYIETKA SEYISKMTTN PIYEHIGYAT LLREKVSRRL SRSKHESRKT
SVTNEEHTAV EKISSLVRRA ALTHNDNHFN YEKTHNFKVH TFRGPHWCEY CANFMWGLIA
QGVQCSGLKS EGLYRVSGFT EHIEDVKMAF DRDGEKADIS ANNYPDINII TGALKLYFRD
LPIPVITYDT YSKFIEAAKV PNADERLEAV HEVLMLLPPA HYETLRYLMI HLKKVTMNEK
DNLMNAENLG IVFGPTLMRS PEDSTLTTLH DMRYQKLIVQ ILIENEDVLF
//
