ID A0A2Y9DN65_TRIMA Unreviewed; 76 AA.
AC A0A2Y9DN65;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Heat shock factor-binding protein 1 {ECO:0000256|ARBA:ARBA00039223};
GN Name=LOC101347757 {ECO:0000313|RefSeq:XP_004377781.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004377781.1};
RN [1] {ECO:0000313|RefSeq:XP_004377781.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC affects HSF1 DNA-binding activity. May have a role in the suppression
CC of the activation of the stress response during the aging process.
CC {ECO:0000256|ARBA:ARBA00037689}.
CC -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC trimers and HSP70 coincides with attenuation of heat shock response and
CC the conversion of HSF1 trimer to monomer.
CC {ECO:0000256|ARBA:ARBA00038772}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSBP1 family.
CC {ECO:0000256|ARBA:ARBA00006349}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004377781.1; XM_004377724.3.
DR AlphaFoldDB; A0A2Y9DN65; -.
DR SMR; A0A2Y9DN65; -.
DR STRING; 127582.A0A2Y9DN65; -.
DR GeneID; 101347757; -.
DR KEGG; tmu:101347757; -.
DR InParanoid; A0A2Y9DN65; -.
DR OrthoDB; 11594at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 1.20.5.430; -; 1.
DR InterPro; IPR009643; HS1-bd.
DR PANTHER; PTHR19424; HEAT SHOCK FACTOR BINDING PROTEIN 1; 1.
DR PANTHER; PTHR19424:SF3; HEAT SHOCK FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF06825; HSBP1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Stress response {ECO:0000313|RefSeq:XP_004377781.1}.
FT COILED 31..65
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 76 AA; 8514 MW; 9838537886B2D402 CRC64;
MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG
VEELEGENKI PATQKS
//
