ID A0A2Y9DNC1_TRIMA Unreviewed; 794 AA.
AC A0A2Y9DNC1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Paraplegin isoform X2 {ECO:0000313|RefSeq:XP_004377865.1};
GN Name=LOC101348857 {ECO:0000313|RefSeq:XP_004377865.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004377865.1};
RN [1] {ECO:0000313|RefSeq:XP_004377865.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR RefSeq; XP_004377865.1; XM_004377808.3.
DR AlphaFoldDB; A0A2Y9DNC1; -.
DR GeneID; 101348857; -.
DR KEGG; tmu:101348857; -.
DR OrthoDB; 9585at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF8; PARAPLEGIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 341..481
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 106..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 212..239
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 107..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 88119 MW; 053EFDE500858DC1 CRC64;
MAAVLLLLRA LRQGRRLGPG WLRSPGSGRS PGLFARVGRR RPYVTQGPPG GLAGAGGRAL
QSLELQLLTP TFQGISGLLL KQHLIQNPVS LWKILGGTYY FNTSRMKQRN KDNDKSRAKT
PEDDEEERKR KEREDQMYRE RLRTLFIIAV VMSLLNSLSS SGGNISWNDF VNEMLAKGEV
QRVQVVPESD VVEVYLHPGA VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIEVKDR
IPVSYKRTGF FGNALYALGM TAVGLAILWY IFRLAGMTGR EGGFSAFNQL KMARFTVVDG
KMGKGISFKD VAGMHEAKLE VKEFVDYLKS PERFLQLGAK VPKGALLLGP PGCGKTLLAK
AVATEAQVPF LAMAGPEFVE VIGGLGAARV RSLFKEARHR APCIVYIDEI DAVGKKRSTT
MSSFSNTEEE QTLNQLLVEM DGMGTTDHVI VLASTNRADI LDSALMRPGR LDRHVFIDLP
TLQERREIFE QHLKSLKLTR ASSFYSQRLA ELTPGFSGAD IANICNEAAL HAAREGHTSV
HTSNFEYAVE RVLAGTAKKS KILSKEEQRV VAFHESGHAL VGWLLEHTEA VMKVSIAPRT
NAALGFAQML PRDQHLFTKE QLFERMCMAL GGRASEAISF NRVTSGAQDD LRKVTRIAYS
MVRQFGMAPS IGPVSFPDAQ ESPTGIGRRP FSQGLQHLMD HEAKLLVAKA YRHTEQVLQD
NLDKLQALAN ALLEKEVINY EDIEALIGPP PYGPKKMIMP QRWADAEREK QDSGDEEAAQ
QPPLRGEEPD KEPS
//
