ID A0A2Y9DQF9_TRIMA Unreviewed; 759 AA.
AC A0A2Y9DQF9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Pleckstrin homology domain-containing family M member 3 {ECO:0000313|RefSeq:XP_004378338.1};
GN Name=LOC101358404 {ECO:0000313|RefSeq:XP_004378338.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004378338.1};
RN [1] {ECO:0000313|RefSeq:XP_004378338.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004378338.1; XM_004378281.2.
DR AlphaFoldDB; A0A2Y9DQF9; -.
DR STRING; 127582.A0A2Y9DQF9; -.
DR GeneID; 101358404; -.
DR KEGG; tmu:101358404; -.
DR InParanoid; A0A2Y9DQF9; -.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd14674; PH_PLEKHM3_1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037812; PLEKHM3_PH_1.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF10; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 359..454
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 457..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 86617 MW; D24D222DFBC44584 CRC64;
MEALEVDDIS PALEVTEDFF SSFDSKIEKA VQQAEVYGIQ EVPELVGHEV FSNIPDNGAI
RNVASLGKGG MIWDHCNSRL LETKAQNIFP AKEQFMVQRG ATPDNLSWME QKETSTFNFF
NICQRRRDRP RSVNDLLDET STFKPGHARS RSDITQVDWR VVLKTTPLQQ QQQLSLQGPH
FTRLSFLSPS TSKVEDAQGN TEHKQTFPNI LKKGYLEIRK DHDSYWQSCY AELSPYNLCF
YSLDSSGNQN LYATYQLSHF QSISVLGNLE ARMVDTVLYD NTQLQLKAES PWEALDWGQK
LWEVVHAAGP GYVVRQDELA NSPGLGHNVD YTQNHCLQKK SSGLLPSSPV LDSPKQYQNI
LKSGTLYRLT VQNNWKAFTF VLNGAYLLAF QPGKLDEDPL LSYNVDVCLA VQMDDLDDCD
SCFQVIFPQD VLRLRAETRQ RAQEWMEALK TAASAARSSE QNLQVTLRSK SKDQMGGHDG
RKNKRQSVTT SFLSILTTLS LERGLTAQSF KCAGCQRSIG LSNGKAKVCN YSGWYYCGSC
HVDDNFLIPA RIVHNWDTSK YKVSKQAKEF LEYVYEEPLI DIQQENPMLY LHAEPLAAVV
RLRQQLKSLR AYLFSCRAAV AEDLRRRIFP REYLLQQIHL YSLADLQQVI EGKLAPFLGK
VIKFATSHVY SCSLCSQKGF ICEICNNGEI LYPFEDISTS RCERCGAVFH SECKEKSVPC
PRCVRRELQK KQKSFWRRLN MDESLEEAFN MFELSYQNT
//
