ID A0A2Y9DQH1_TRIMA Unreviewed; 402 AA.
AC A0A2Y9DQH1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=LIM/homeobox protein Lhx5 {ECO:0000256|ARBA:ARBA00040544};
GN Name=LOC101345211 {ECO:0000313|RefSeq:XP_004379108.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004379108.1};
RN [1] {ECO:0000313|RefSeq:XP_004379108.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004379108.1; XM_004379051.1.
DR AlphaFoldDB; A0A2Y9DQH1; -.
DR STRING; 127582.A0A2Y9DQH1; -.
DR GeneID; 101345211; -.
DR KEGG; tmu:101345211; -.
DR InParanoid; A0A2Y9DQH1; -.
DR OrthoDB; 932158at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd09367; LIM1_Lhx1_Lhx5; 1.
DR CDD; cd09375; LIM2_Lhx1_Lhx5; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR049618; Lhx1/5_LIM1.
DR InterPro; IPR049619; Lhx1/5_LIM2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR PANTHER; PTHR24208:SF115; LIM_HOMEOBOX PROTEIN LHX5; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 3..62
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 63..125
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 178..238
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 44385 MW; 06633F7199B7DD77 CRC64;
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL YCKNDFFRRF
GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKDDYL
SSSSLKEGSL NSVSSCTDRS LSPDLQDPLQ DDPKETDNST SSDKETANNE NEEQNSGTKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQGDYYGPG SNYDFFAHGP
PSQAQSPADP NFLAASGPGS TPLGALEPPL AGPHAADNPR FTDMISHPDT PSPEPGLPGA
LHSMPGEVFS GGPSPPFPMG GTSGYSGPLS HPNPELNEAA VW
//
