ID   A0A2Y9DRQ4_TRIMA        Unreviewed;      1267 AA.
AC   A0A2Y9DRQ4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Insulin receptor substrate 4 isoform X1 {ECO:0000313|RefSeq:XP_004379819.1};
GN   Name=LOC101350401 {ECO:0000313|RefSeq:XP_004379819.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004379819.1};
RN   [1] {ECO:0000313|RefSeq:XP_004379819.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004379819.1; XM_004379762.1.
DR   AlphaFoldDB; A0A2Y9DRQ4; -.
DR   STRING; 127582.A0A2Y9DRQ4; -.
DR   GeneID; 101350401; -.
DR   KEGG; tmu:101350401; -.
DR   InParanoid; A0A2Y9DRQ4; -.
DR   OrthoDB; 4212441at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd01257; PH_IRS; 1.
DR   CDD; cd01204; PTB_IRS; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039011; IRS.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR   PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR   Pfam; PF02174; IRS; 1.
DR   PRINTS; PR00628; INSULINRSI.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Receptor {ECO:0000313|RefSeq:XP_004379819.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          78..199
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          232..336
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          403..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1200..1267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..651
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..784
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        802..832
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1267 AA;  133402 MW;  61C0B880A52036AD CRC64;
     MASCSFARDE VTSSLRAAAA AAAAASPAAA TTPLLSSGTP TALIGTGSSC PGAMWLSAAT
     GSRSDSESEE EDLPVGDEVC KRGYLRKQKH GHRRYFVLKL ETADAPARLE YYENARKFRH
     SVRAAAAAAA AAASGAAMPA LIPPRRVITL YQCFSVSQRA DARYRHLIAL FTQDEYFAMV
     AENESEQESW YLLLSRLILE SKRRRCGTPG VQPDQEGAAL VAAAAAAEPP FYKDVWQVVI
     KPRGLGHRKE LSGVFRLCLT DEEVVFVRLN TEVASVVVQL LSIRRCGHSE QYFFLEVGRS
     TVIGPGELWM QVDDCVVAQN MHELFLEKMR ALCADDYRAR CRSYSISIGT HLLTLLSARR
     HLDSLPFQPG GWLRRSRFEF CHLRAIGDGE DEMLLTRRFV SASEPVPHSR RGRQHLPRMH
     RSRRAMSVPA SCFRHLAPNP MLAPAEPPND GACLSSEASG SGNSGEEGNP QSNESQEGNG
     GDYMPMNNWG SGNGRGSGGG QGSSGQGSSS QGSGGNQCSG GGQGSGGGQS SSGGQGSGGQ
     GSGGQGAGGN QCSGNGQGTA GGHGSGSGQG AGGGHGSGSG QGPGGGHGSG GGGKDSGGGK
     GSGSGKGSDG NDERGKSLKK RSYFGKLTQS KQQQMPPPPP PPPPPPPPGA TGGKGKSGGR
     FRLYFCADRG ATKERKESKD VKEAEIPEGA ARCPHRARAF DEDEDDPYVP MRPGVAAPLA
     SSSDYMPMAP QNVSASKKRH SRSPFEDSRG YMMMFPRVSP PPAPSPPKAP DPNKEDDSKD
     NDSDSDYMFM APGAGAIPKN PRNPQGGSSS KSWSSYFSLP NSFQSSPLGQ SDHSEYVPML
     PGKFLGRGPD KEASSSRGPK DTPSKPLVQG SCAKPGDGGS PSKPSDDGPP KNKAKRPNRL
     PFVTKGNKIK PKPQKPTHQQ RGAVSSRDYV NIDFTKRESN MPVPSSQRLP DSWGIIADPR
     LSAFSHYVNV EFGVPFPNPA NHLSNLLRAI PGANPPSLDG ARWPLPPLPP SATGGNAEEE
     GDYIEVIFNP AMTPAVPFAD SAIRYDAETG RIYVVDPFSE CCMDISLSPS RCSEPPPVAR
     LLQEEEQERR RPRSRSQSFF AAARAAVSAF PTDSLERELS ASLASAAAAA AAPTLAVGRA
     LAAASALAAA PGVGAAAASL EAAAGFDSAS ARWFLPVANA AAAAAAEAVR GFQNIACGSN
     PEAPNPSADP ARGENGVSGA AAPPPPPRRR PVPRPPERED SDDDNTYVRM DFARPDSKKF
     DSPERGW
//