ID A0A2Y9DU59_TRIMA Unreviewed; 387 AA.
AC A0A2Y9DU59;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=LOC101351340 {ECO:0000313|RefSeq:XP_004380460.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004380460.1};
RN [1] {ECO:0000313|RefSeq:XP_004380460.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004380460.1; XM_004380403.1.
DR AlphaFoldDB; A0A2Y9DU59; -.
DR STRING; 127582.A0A2Y9DU59; -.
DR GeneID; 101351340; -.
DR KEGG; tmu:101351340; -.
DR InParanoid; A0A2Y9DU59; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19346; Wnt_Wnt2b; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR009140; Wnt2.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF93; PROTEIN WNT-2B; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01842; WNT2PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 387 AA; 43460 MW; F10ED63D74E6F97F CRC64;
MLRPGGAQEA AQLPFWRARA PVPAPPDGCR SPARLGLACL LLLLLLTLPA PVDTSWWYIG
ALGTRVICDN IPGLVSRQRQ LCQRYPDIMR SVGEGAREWI RECQHQFRHH RWNCTTLDRD
HTVFGRVMLR SSREAAFVYA ISSAGVVHAI TRACSQGELS VCSCDPSTRG RHRDQRGDFD
WGGCSDNIHY GVRFAKAFVD AKEKRLKDAR ALMNLHNNRC GRTAVRRFLK LECKCHGVSG
SCTLRTCWRA LSDFRRTGDY LRRRYDGAVQ VTATQDGANF TAARQGYRRA TRTDLVYFDN
SPDYCVLDKA AGSLGTAGRV CSKTSKGTDG CEIMCCGRGY DTTRVTRVTQ CECKFHWCCA
VQCKECRNTV DIHTCKAPKK AEWLDQT
//
