ID   A0A2Y9DU66_TRIMA        Unreviewed;       497 AA.
AC   A0A2Y9DU66;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=DENN domain-containing protein 2D {ECO:0000313|RefSeq:XP_004380473.2};
GN   Name=LOC101355021 {ECO:0000313|RefSeq:XP_004380473.2};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004380473.2};
RN   [1] {ECO:0000313|RefSeq:XP_004380473.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004380473.2; XM_004380416.3.
DR   AlphaFoldDB; A0A2Y9DU66; -.
DR   STRING; 127582.A0A2Y9DU66; -.
DR   GeneID; 101355021; -.
DR   KEGG; tmu:101355021; -.
DR   InParanoid; A0A2Y9DU66; -.
DR   OrthoDB; 5398783at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR15288:SF2; DENN DOMAIN-CONTAINING PROTEIN 2D; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          83..473
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  56301 MW;  58594BB5711D8F50 CRC64;
     MKVKVSGPAE VEDWGAGPAQ TWARAPGTRG AMDGLGRRLR ASLKLKRGSR GSSQANAEEA
     VKEPERAREL PLPRFVGGQH FFEYLLVVSL KKKHSGDDYE PTITYQFPKR ENLLRGQQEE
     EERLLSAIPL FCFPDGNEWA PLTEYPRETF SFVLTNVDGS RKIGYCRRVL PTGRGPRLPT
     VYCILSCIGC FGLFSKILDE VEKRHQISMA VIYPFMQGLR EAAFPAPGKT VTLKSFIPDS
     GTEFISLTRP LDSHLEHVDF NSLLQCLSFE QILQIFASAV LERRIIFLAE GLSTLSQCIH
     ATAALLYPFS WAHTYIPVVP ESLLATVCCP TPFMVGVQMR FQQEVMDSPM EEVLLVNLCE
     RTFLMSVGDE KDILPPKLQH DILDSLDQGT KHLQTSEQIN EHVSGPFVQF FVKTVGHYAS
     YIKWEANGHG HFQERSFCKA LTSKAKRRFV KKFVKTQLFS LFIQEAEKSK SPPAGYFQRK
     ILEYEEQKKQ NKPGKRL
//