ID A0A2Y9DV33_TRIMA Unreviewed; 262 AA.
AC A0A2Y9DV33;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Troponin T, slow skeletal muscle {ECO:0000256|ARBA:ARBA00040072};
DE AltName: Full=Slow skeletal muscle troponin T {ECO:0000256|ARBA:ARBA00043016};
GN Name=LOC101355794 {ECO:0000313|RefSeq:XP_004381810.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004381810.1};
RN [1] {ECO:0000313|RefSeq:XP_004381810.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00003363}.
CC -!- SUBUNIT: Interacts with TPM3. {ECO:0000256|ARBA:ARBA00044035}.
CC -!- SIMILARITY: Belongs to the troponin T family.
CC {ECO:0000256|ARBA:ARBA00008330}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004381810.1; XM_004381753.1.
DR AlphaFoldDB; A0A2Y9DV33; -.
DR STRING; 127582.A0A2Y9DV33; -.
DR GeneID; 101355794; -.
DR KEGG; tmu:101355794; -.
DR InParanoid; A0A2Y9DV33; -.
DR OrthoDB; 5362548at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; TROPONIN T; 1.
DR PANTHER; PTHR11521:SF6; TROPONIN T, SLOW SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 200..234
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..33
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 31420 MW; 982A9FF38411619E CRC64;
MSDTEEQEYE EEQQEEEAVE EEEEAPEEPE PEAEREEERP KPSRPVVPPL IPPKIPEGER
VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRAER AEQQRFRTEK
ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE
MKQRILSERK KPLNVDHMGE DQLREKAQEL SDWIHQLESE KFDLMEKLKQ QKYEINVLYN
RISHAQKFRK GAGKGRLGGR WK
//
