ID A0A2Y9DW98_TRIMA Unreviewed; 1596 AA.
AC A0A2Y9DW98;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 1 isoform X2 {ECO:0000313|RefSeq:XP_004382330.1};
GN Name=LOC101358077 {ECO:0000313|RefSeq:XP_004382330.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004382330.1};
RN [1] {ECO:0000313|RefSeq:XP_004382330.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR RefSeq; XP_004382330.1; XM_004382273.3.
DR GeneID; 101358077; -.
DR KEGG; tmu:101358077; -.
DR OrthoDB; 92033at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|RefSeq:XP_004382330.1};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_004382330.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 1238..1360
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1430..1596
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..274
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..399
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..475
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1596 AA; 175225 MW; 158EF33D1EB43524 CRC64;
MNKAPQPTGP PPAPSPGLPQ PAFPPGQTAP VVFSAPQATQ MNTPSQPRQH FYPSRAQPPS
SAASRVPSAA PARPGPAAHV YPAGSQVMMI PSQIYQASQG AYYVPGQGRS TYVVPTQQYP
VQPGAPGFYT GASPTEFGTY AGAYYPAQGV QQFPAGVAPA PVLMNQPPQI APKRERKTIR
IRDPNQGGKD ITEEIMSGAR TASTPTPPQA GGGLEPQANG ETHQAAVVLR TDDRPQGAII
GGRPGPPGPE HSPSESQPSS PSPTPSPPPV LGPGSEPNLE VLSIPGDTVT TGTIQMSVDE
LTPMPREAGE PYRLSAEPTG LSEPILEVEV TLSKPVPDPE PSSSPLSPPS PLTSHEVEVP
HEPNGVVPPE GLEPEVEPSP ELAALPPPAC PPEPPVPVAP TVQSEELLNG APSPPPVDLS
PVSEPEEQAE EATASVALPT VLAAAPAVAP PAPSPAQAEE MEEEEQEEEE AAEGEKGGEE
PLPQENTPAP AHLSQNLEAA AAPQVAVSVP KRRRKMKELN KKETVGDLLD AFKEVNPAVP
EVENQPPVDN SPGPEPEGSS VPPRSEEADE TWDSKEDKIH NAENIQPGEQ KYEYKSDQWK
PLNLEEKKRY DREFLLGFQF LFASMQKPEG LPQISDVVLD KANKTPLRPL DPTRLPGINC
GPDFTPSFAN LGRPALSARG PPRGGPGGEL PRGPAGLGPR RSQPGPRKEP RKIIATVLMT
EDIKLNKAEK AWKPSSKRTA ADKDRGEEDA DGSKTQDLFR RVRSILNKLT PQMFQQLMKQ
VTQLAIDTEE RLKGVIDLIF EKAISEPNFS VAYANMCRCL MALKVPTTEK PTMTVNFRKL
LLNRCQKEFE KDKDDDEVFE KKQKEMDEAA TPEERGRLKE ELEEARDIAR RRSLGNIKFI
GELFKLKMLT EAIMHDCVVK LLKNHDEESL ECLCRLLTTI GKDLDFEKAK PRMDQYFNQM
EKIIKEKKTS SRIRFMLQDV LDLRRSNWVP RRGDQGPKTI DQIHKEAEME EHREHIKVQQ
LMAKGSDKRR GGPPGPPISR GLPLVDDGGW NTVPISKGSR PIDTSRLTKI TKPGSIDSNN
QLFAPGGRLS WGKGSSGGSG AKPSDAASEA ARPATSTLNR FSALQQAVPT ESTDNRRVVQ
RSSLSRERGE KAGDRGDRLE RSERGDRGDR LDRARTPATK RSFSKEVEER SRERPSQPEG
LRKAASLTED RDRGRDAAKR EATMPPASPP KAALSEEELE KKSKAIIEEY LHLNDMKEAV
QCVQELASPS LLFIFVRHGI EATLERSAIA RERVGQLLHQ LLCAGRLPTT QYYRGLCEIL
ELAEDMEIDI PHVWLYLAEL VTPILQEGGV PIGELFREIT KPLRPLGKAA YLLVEILRLL
CKSLGPKKVG TLWREAGLSW KEFLPEDQDV SAFVAEQEVE YTLGEKADTP GQRELTSEEL
SRQLERLLKE GSSNERVCDW IEANLSEQQA ASTTLVRALM RIVCYSAIIF ETPLRVDVAV
LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPANLLR MFFDALYDED VVKEDAFYSW
ESSKDPAEQQ GKGVALKSVT AFFKWLREAE EESDHN
//
