ID A0A2Y9DWQ1_TRIMA Unreviewed; 1605 AA.
AC A0A2Y9DWQ1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rho guanine nucleotide exchange factor 5 {ECO:0000313|RefSeq:XP_004382470.2};
GN Name=LOC101354281 {ECO:0000313|RefSeq:XP_004382470.2};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004382470.2};
RN [1] {ECO:0000313|RefSeq:XP_004382470.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004382470.2; XM_004382413.3.
DR STRING; 127582.A0A2Y9DWQ1; -.
DR GeneID; 101354281; -.
DR KEGG; tmu:101354281; -.
DR CTD; 7984; -.
DR InParanoid; A0A2Y9DWQ1; -.
DR OrthoDB; 12272at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11940; SH3_ARHGEF5_19; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR029212; ARHGEF5/35_N.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF2; DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF15441; ARHGEF5_35; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1182..1366
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1518..1579
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 16..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..844
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..875
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1605 AA; 174766 MW; 2002447926B5FD16 CRC64;
METAEPPQEA LAPTAAILGF MRGSQAPAPG PEAPESPSYE EVEGRRHSET SWGELRNASG
FPAEIMPPFP KDSSADKETY QETPGTNQET PTMDQETPGT NQETPTANQE TPAANQETPT
ANQETPETPT TNQETPAANQ ETPTTNQETP TANQETPTMD QETLTMDQET PTANQETPAA
EQGAANSQAR TPAYPELCDH LVPGHSLDVV PDPSEWDSRP EAELVAWGAG HTDEQEGAYP
DNPALTTLGP PWRECPAGTP QPQEEPQERH GQAGCMHPQG APGWEGQGQQ EVGFQKVQEL
TDKQVNGRRG EQRQNAEQGQ EGLGTRGLGG LTQGQWGQEE NAARPQGPRR GGQGEAGEMP
GPEENEVDAQ PEEKLEEVPG KQEDQGLGRE LIPVEEWGEE AGVSEGEEAG VGEGEPGDQA
GDRLGAGEEQ AEHNGPSTVA PRPPGIPPPC DVFFKASCPI TGVPQAQIDS WAGDMSPSSP
VPAWVSSDKD ASQKGQGEGH KQGPGARAIS ASTLGTPPWT LDSAPGSPTQ VSPCSITSLP
ASPAEEIRPA TGSPEASRAS LSMDSPILCE ALETPMATPR GSPSTEATWD LCPSPSGSRP
QSSLASPSGS PLQSPVAGPS GSPLQNPVAS PSEVGPHLRS SSFTGPPRTK LPPDLAARSL
SFSHSEPPQR PPKPAIYGSV TPRRNRRSGR DSSITLEPPT ASPALWQSLG VPHSQPEGPG
GAHPCQHSSA PAPPLVSVDR RVPEPPPPLE KRHVLSPTGE RDTCLQTMPP TLQQPSYPAP
LALGSGFHGT PKVPADPLVA RQLRPLPSTL DLPHSTQTSL PPRHRYNKPL PPTPDGPQPL
PSPSSSSRSP RTYKPLPPLP TLDPPTEPPP LPPKARARSR STQRALMSAG GQARLRPGSQ
DWSAALAPLA GHTSWPPATG LSPNPLAPAS RGRSDMAPSM AFSNVTNLLS LSSPTTAWPP
EEGSWLTEET GGPTRGPSKR ETTQEGANSP QGSELGWARP PERPGHHPLE KSSSWPHRRD
TGRPLPGVSG TALREGHSKS KGWNRQGLRR PSILSEDASG TRGPAMERAP GPSDTIIFRE
KKPKEASGGF SRRCSKLINS SQLLYQEYSD VFLNKEIQSQ QRPDSLAEPP GLASPRQPRK
ALVSSESYLQ RLSSASSSSL WQEIPVVRNS TVLLSMTHED QKLQEAKFEL IISEASYLRS
LNVAVDHFQL STQLRAALSN QDHQWLFSRL QDVRDVSATF LSDLEENFEN NIFTFHVCDV
VLNHAPHFRR VYLPYVTNQT YQERTFQSLL NSNSHFREVL ERLESDPVCQ RLSLKSFLIL
PFQRITRLKL LLQNILKRTQ PGSLEEAEAT KAHHALEELI RDCNSNVQRM RRTEELIYLS
QKIEFECRIF PLISQSRWLV KSGELTALEF SASPGLRRKL NTRPVHLHLF NDRLLLSRPR
EGSRFLVFDH APFSAVRGEK CEMKLHGAHK NLFRLFLLHN TQGSQAEFLF RTETQSEKLR
WISALALPKE EMDLLECYDS PQVQCLRAYK PRENDELALE KADVVMVTQQ SSDGWLEGVR
LSDGERGWFP QQQVEFISNR DVCARNLKEA QRVKTARLQL VEQQA
//
