ID   A0A2Y9DX50_TRIMA        Unreviewed;       182 AA.
AC   A0A2Y9DX50;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Adenosine 5'-monophosphoramidase HINT3 {ECO:0000256|ARBA:ARBA00039802};
DE   AltName: Full=Histidine triad nucleotide-binding protein 3 {ECO:0000256|ARBA:ARBA00042361};
GN   Name=LOC101350326 {ECO:0000313|RefSeq:XP_004382807.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004382807.1};
RN   [1] {ECO:0000313|RefSeq:XP_004382807.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+);
CC         Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57890, ChEBI:CHEBI:456215;
CC         Evidence={ECO:0000256|ARBA:ARBA00024472};
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DR   RefSeq; XP_004382807.1; XM_004382750.2.
DR   AlphaFoldDB; A0A2Y9DX50; -.
DR   STRING; 127582.A0A2Y9DX50; -.
DR   GeneID; 101350326; -.
DR   KEGG; tmu:101350326; -.
DR   InParanoid; A0A2Y9DX50; -.
DR   OrthoDB; 2782915at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd01278; aprataxin_related; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR12486:SF5; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3; 1.
DR   PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR   Pfam; PF11969; DcpS_C; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          49..160
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           143..147
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   COMPBIAS        11..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   182 AA;  20673 MW;  DC5FB584B729C3A7 CRC64;
     MAEEQRCYGT ESDPNCKTAT TAEPTMSPTQ TSEVAAGSLE LEDYDLKCLF CRIARGQEPS
     TELLPCENED LVCFKDIKPA APHHYLVVPK KHVGNCNDLK KDHVELVENM VAVGKTILKR
     NNFTDFKNVR MGFHMPPFCS ISHLHLHVLA PVNQLGFISK LIYRANSYWF ITVDYLIEKL
     RT
//