ID A0A2Y9DX67_TRIMA Unreviewed; 1221 AA.
AC A0A2Y9DX67;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sorbin and SH3 domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_004382828.1};
GN Name=LOC101356741 {ECO:0000313|RefSeq:XP_004382828.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004382828.1};
RN [1] {ECO:0000313|RefSeq:XP_004382828.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004382828.1; XM_004382771.2.
DR AlphaFoldDB; A0A2Y9DX67; -.
DR STRING; 127582.A0A2Y9DX67; -.
DR GeneID; 101356741; -.
DR KEGG; tmu:101356741; -.
DR InParanoid; A0A2Y9DX67; -.
DR OrthoDB; 5407056at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 166..227
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 983..1042
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1058..1119
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1162..1221
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 25..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..809
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 136932 MW; BB94A01B86091CE6 CRC64;
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSHS PDSAWRSYND RNQGTLNGDA
TYSSLAAKGF RSVRPNLQEK RSPIQSQITV NGTSGGAVSP MSYYQRPFSP SAYSLPGSFS
SSVTMQHGRS FDSTETYPQH AQSLDGTTSS SIPLYRSSEE EKRVTVIKAP HYPGIGPVDE
SGIPTAIRTT VDRPKDWYKT MFKQIHMVHK PDDDTDMYNT PYTHNAGLYN PPYGAQSHPA
AKTQTYRPLS KSHSDNGAHT FKDTSSPVPP PVPPPVPPLR PRERSSTEKH DWDPPDRKVD
TRKFRSEPRS IFEYEPGKSS ILQHERPPPK KALDYVQDHS SGVPNEASLY QSSIDRSLER
PSSSASMASD FRKRRRSEPA VGRPRGLGDP SASRTSPGTV DHLGSSATLT KSFISSSPSS
PSRAKGGDDS KMCPSLCSYS GLNGNPSTEL DYCSTYRQHL DVPWDSPRAI TFKNGWQMAR
QNAEVWSSTE ETVSPKIKSR SCDDLLNNDC DSFPDPKTKS ESMGSLLCEE DSKESCAPPW
AAPSVQESHS NGRSRTRHRS AHDAPGFLKM YKKMHRINRK DLMNSEVICS VKSRVIQYEK
EQQHQGLLHG WSQSSTEEVP RDMVPTRISE FEKLIQKSKS MPNLGDEMLS PGTLEPPQNG
LCPKRRFSIE SLLEEENQSR YPSQVQRSYK PKTLVPIHIE VTSDEQPRTH VEFSDSDQDG
VVSDHSDFIH VEGSSFCSES DFDHFSFTSS ESFYGSSHHH HHHHHHHHRH LISSCKGRCP
ASYTRFTTML KHERAKQENT DEPRRQETDP GLSKLAFLVS PVPFRRKKNP TPKKQTEKAK
CKASVIEALD SALKDICDQI KAEKRRGSLP DNSILHRLIS ELLPDVPERN SSLKALQRSP
MHQPPRPLPH DGAIHCPLDQ NDCGRMPHSA SFQDVGTSNN HHHHPDHDGA LSLQDRESPR
GYSSTLTDLG RSASRERRGT PDKEKLPAKA VYDFKAQTSK ELSFKKGDTV YILRKIDQNW
YEGEHHGRVG IFPISYVEKL IPPEKAQPAR PPPPAQPGEI GEAIAKYNFN ADTNVELSLR
KGDRVILLKR VDQNWYEGKI PGTNRQGIFP VSYVEVIKKN TTKGAEDYPD PPIPHSYSSD
RIHSLSSNKP QRPVFTHENI QGGGEPFQAL YNYTPRNEDE LELRESDVID VMEKCDDGWF
VGTSRRTKFF GTFPGNYVRR L
//
