ID A0A2Y9DYC2_TRIMA Unreviewed; 2612 AA.
AC A0A2Y9DYC2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Filamin-C isoform X4 {ECO:0000313|RefSeq:XP_004382704.1};
GN Name=LOC101344651 {ECO:0000313|RefSeq:XP_004382704.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004382704.1};
RN [1] {ECO:0000313|RefSeq:XP_004382704.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR RefSeq; XP_004382704.1; XM_004382647.1.
DR GeneID; 101344651; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 250..348
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 350..448
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 449..545
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 546..638
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 642..738
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 739..841
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 842..940
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 941..1036
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1037..1129
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1130..1224
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1225..1324
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1325..1417
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1418..1513
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1514..1610
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1611..1706
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1753..1822
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1822..1914
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1912..2001
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2004..2096
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2094..2193
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2196..2288
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2290..2383
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2387..2479
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2517..2611
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 969..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2612 AA; 278411 MW; A294281C5DBE5A58 CRC64;
MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVGKRLTDL QRDLSDGLRL IALLEVLSQK
RMYRKFHPRP NFRQMKLENV SVALEFLERE HIKLVSIDSK AIVDGNLKLI LGLIWTLILH
YSISMPMWED EDDEDARKQT PKQRLLGWIQ NKVPQLPITN FNRDWQDGKA LGALVDNCAP
GLCPDWEAWD PNQPVENARE AMQQADDWLG VPQVIAPEEI VDPNVDEHSV MTYLSQFPKA
KLKPGAPVRS KQLNPKKAIA YGPGIEPQGN TVLQPAHFTV QTVDAGLGEV LVYIEDPEGH
TEEAKVVPNN DKDRTYSVSY VPKVAGLHKV TVLFAGQNIE RSPFEVNVGM ALGDANKVSA
RGPGVEPVGN VANKPTYFDI YTAGAGTGDV AVVIVDPQGR RDTVEVALED KGDSTFRCTY
RPVMEGPHTV HVAFAGAPIT RSPFPVHVAE ACNPNACRAS GRGLQPKGVR VKEVADFKVF
TKGAGSGELK VTVKGPKGTE EPVKVREAGD GVFECEYYPV VPGKYVVTIT WGGYAIPRSP
FEVQVSPEAG VQKVRAWGPG LETGQVGKSA DFVVEAIGTE VGTLGFSIEG PSQAKIECDD
KGDGSCDVRY WPTEPGEYAV HVICDDEDIR DSPFIAHIQP APPDCFPDKV KAFGPGLEPT
GCIVDKPAEF TIDARLAGKG DLKIYAQDAE GFPIDIKVIP NGDGTFRCSY VPTKPIKHTI
IISWGGVNVP KSPFRVNVGE GSHPERVKVY GPGVEKTGLK ANEPTYFTVD CSEAGQGDVS
IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR YTIMVLFANQ EIPASPFHIK
VDPSHDASKV KAEGPGLNRT GVEVGKPTHF TVLTKGAGKA KLDVRFAGAS KGEAVRDFEI
IDNHDYSYTV KYTAVQQGNM AVTVTYGGDP VPKSPFVVNV APPLDLSKVK VQGLNSKVAV
GQEQAFSVST RGAGGQGQLD VRMTSPSRRP IPCKLEPGGG ADTQAVRYMP PEEGPYKVDI
TYDGHLVPGS PFAVEGVLPP DPSKVCAYGP GLKGGLVGTP APFSIDTKGA GTGGLGLTVE
GPCEAKIECQ DNGDGSCAVS YLPTEPGEYT INILFAEAHI PGSPFKATIR PVFDPSKVRA
SGPGLERGKV GEAATFTVDC SEAGEAELTI EILSDAGVKA EVLIHNNADG TYHITYSPAF
PGTYTITIKY GGHPVPKFPT RVHVQPAVDT SGIKVSGPGV EPHGVLREVT TEFTVDARSL
TATGGNHITA RVLNPSGAKT DTYVTDNGDG TYRVQYTAYE EGVHLVEVLY DDVAVPKSPF
RVGVTEGCDP TRVRAFGPGL EGGLVNKANR FTVETRGAGT GGLGLAIEGP SEAKMSCKDN
KDGSCTVEYI PFTPGDYDVN ITFGGRPIPG SPFRVPVKDV VDPGKVKCSG PGLGAGVRAR
VPQTFTVDCS QAGRAPLQVA VLSPTGVAEP VEVRDKGDGT HTVHYTPATD GPYTVAVKYA
DQEVPRSPFK IKVLPAHDAS KVRASGPGLN AAGIPASLPV EFTIDARDAG EGLLTVQILD
PEGKPKKANI RDNGDGTYTV SYLPDMSGRY TITIKYGGDE IPYSPFRIHA LPTGDASKCL
VTGACLGPRI QIGEETVITV DAKAAGKGKV TCTVSTPDGA ELDVDVVENH DGTFDIYYTA
PEPGKYVITI RFGGEHVPNS PFHVLVSSGQ PQVMAQSKCS GLPQPMPIPS HPPKATEEPV
VPVEPMESML RPFNLVIPFT VQKGELTGEV RMPSGKTARP NITDNKDGTI TVRYAPTEKG
LHHMGIKYDG NHIPGSPLQF YVDAINSRHV SAYGPGLSHG MVNKPATFTI VTKDAGEGGL
SLAVEGPSKA EITCKDNKDG TCTVSYLPTA PGDYSIIVRF DDKHIPGSPF TAKITGDDSM
RTSQLNVGTS TDVSLKITES DLSLLTASIR APSGNEEPCL LKRLPNRHIG ISFTPKEVGE
HVVSVRKSGK HVTNSPFKIL VGPSEIGDAS KVRVWGKGLS EGQTFQVAEF IVDTRNAGYG
GLGLSIEGPS KVDINCEDME DGTCKVTYCP TEPGTYIINI KFADKHVPGS PFTVKVTGEG
RMKESITRRR QAPSIATIGS TCDLNLKIPG EASSQDMAAQ VTSPSGKTEA AEIVEGEDSA
YSVRFVPQEM GPHTVAVKYR GQHVPGSPFQ FTVGPLGEGG AHKVRAGGTG LERGVAGMPA
EFSIWTREAG AGGLSIAVEG PSKAEIAFED RKDGSCGVSY VVQEPGDYEV SIKFNDEHIP
DSPFVVPVAS LSDDARRLTV TSLQETGLKV NQPASFAVQL NGARGVIDAR VHTPSGAVEE
CYVSELDSDK HTIRFIPHEN GVHSIDVKFN GAHIPGSPFK IRVGEQSQAG DPGLVSAYGP
GLEGGTTGVS SEFIVNTLNA GSGALSVTID GPSKVQLDCR ECPEGHVVTY TPMAPGNYLI
AIKYGGPQHI VGSPFKAKVT GPRLSGGHSL HETSTVLVET VTKSSSSRGS SYSSIPKFSS
DASKVVTRGP GLSQAFVGQK NSFTVDCSKA GTNMMMVGVH GPKTPCEEVY VKHMGNRVYN
VTYTVKEKGD YILIVKWGDE SIPGSPFKVN VP
//
