ID A0A2Y9DZ49_TRIMA Unreviewed; 472 AA.
AC A0A2Y9DZ49;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ras-GEF domain-containing family member 1B isoform X2 {ECO:0000313|RefSeq:XP_004383161.1, ECO:0000313|RefSeq:XP_023593366.1};
GN Name=LOC101345648 {ECO:0000313|RefSeq:XP_004383161.1,
GN ECO:0000313|RefSeq:XP_023593366.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004383161.1};
RN [1] {ECO:0000313|RefSeq:XP_004383161.1, ECO:0000313|RefSeq:XP_023593366.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004383161.1; XM_004383104.3.
DR RefSeq; XP_023593366.1; XM_023737598.1.
DR GeneID; 101345648; -.
DR KEGG; tmu:101345648; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 34..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 204..452
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 472 AA; 55166 MW; 64DA9AA2AC2F904D CRC64;
MPQTPPFSAM FDSSGYNRNL YQSTEDSCGG LYYHDNNLLS GSLEALIQHL VPNVDYYPDR
TYIFTFLLSS RLFMHPYELM AKVCHLCVEH QRLSDPSSDK NQIRKIAPKI LQLLTEWTET
FPYDFRDERM MRNLKDLAHR IASGEETYRK NVQQIIQCLI RKLATLSQYE EVLAKISATS
TDRLTVLKTK PQSIQRDIIT VCSDPYTLAQ QLTHIELERL NYIGPEEFVQ AFVQKDPLDN
DKTCYSDRKK TRNLEAYVEW FNRLSYLVAT EICMPVKKKH RARMIEYFID VARECFNIGN
FNSLMAIISG MNMSPVSRLK KTWAKVKTAK FDILEHQMDP SSNFYNYRTA LRGAAQRSLT
AHSSREKIVI PFFSLLIKDI YFLNEGCANR LPNGHVNFEK FWELAKQVSE FMTWKQVECP
FERDRKILQY LLTVPVFSED ALYLASYESE GPENHIEKDR WKSLRSSLLG RV
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