ID   A0A2Y9E033_TRIMA        Unreviewed;       833 AA.
AC   A0A2Y9E033;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101340743 {ECO:0000313|RefSeq:XP_004383702.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004383702.1};
RN   [1] {ECO:0000313|RefSeq:XP_004383702.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_004383702.1; XM_004383645.2.
DR   AlphaFoldDB; A0A2Y9E033; -.
DR   STRING; 127582.A0A2Y9E033; -.
DR   GeneID; 101340743; -.
DR   KEGG; tmu:101340743; -.
DR   InParanoid; A0A2Y9E033; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        398..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        444..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        539..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        570..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        636..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        769..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          665..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          246..277
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        666..681
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  93162 MW;  223372E9D6471DC2 CRC64;
     MGTMFRSEEV VLAQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVVDIRRCEE
     LEKTFLFLQE EVRRAGLVLP APEGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA
     QLHQLQLHAA VLGQGHGPPV EASHLDGLSE RTSLLQPSAG PHQDLRVNFV AGAVEPHKAA
     ALERLLWRAC RGFLIASFLE TEQPLEDPVT GEPATWMTFL ISYWGEQIGQ KIHKITDCFH
     CHVFPFEEQE EARRGVLQQL QQQSQELREV LGETERFLSQ VLGRVQRLLP PWQVQIRKMK
     AVYLALNQCS VSATHKCLIA EAWCPTRDLP TIQQALQESS SEVGVSAVVH CIPCRDMPPT
     LIHTNRFTAS FQGIVDAYGV GRYMEVNPAP YTIITFPFLF AVMFGDVGHG LLMFLFALAM
     VLAEDQPAVK AAQNEIWRTF FGGRYLLLLM GLFSVYTGFI YNECFSRAAT IFRSGWSVAA
     MANHSGWSDA FLAQHPILTL DPNVTGVFLG PYPFGIDPIW SLAANHLSFL NSFKMKMSII
     LGVIHMAFGV VLGVFNHVHF GQRHRLLLEF LPQLTFLLGL FGYLVFMVVY KWLRVSAAGA
     AEAPSILIHF INMFLFSRSP TNRPLYSGQE VVQSTLVVLA LAMVPILLLG TPLYLRWQHR
     RHSLRRPSGP QLDEDKAGFM DSRDSGASVN SWGSDEEKGG PPGDEEQAKF AFSEVFMHQA
     IHTIEFCLGC ISNTASYLRL WALSLAHAQL SEVLWTMVMR TGLGMGSRVG VTAAVLVPLF
     AAFAMLTVAI LLVMEGLSAF LHALRLHWVE FQNKFYSGTG YKLTPFTFAV EDE
//