ID A0A2Y9E0J2_TRIMA Unreviewed; 139 AA.
AC A0A2Y9E0J2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467, ECO:0000256|PIRNR:PIRNR001941};
DE Short=IL-4 {ECO:0000256|PIRNR:PIRNR001941};
DE AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00031287, ECO:0000256|PIRNR:PIRNR001941};
DE AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00030247, ECO:0000256|PIRNR:PIRNR001941};
GN Name=LOC101341010 {ECO:0000313|RefSeq:XP_004384825.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004384825.1};
RN [1] {ECO:0000313|RefSeq:XP_004384825.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes.
CC {ECO:0000256|PIRNR:PIRNR001941}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001941}.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family.
CC {ECO:0000256|ARBA:ARBA00009855, ECO:0000256|PIRNR:PIRNR001941}.
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DR RefSeq; XP_004384825.1; XM_004384768.2.
DR AlphaFoldDB; A0A2Y9E0J2; -.
DR STRING; 127582.A0A2Y9E0J2; -.
DR GeneID; 101341010; -.
DR KEGG; tmu:101341010; -.
DR InParanoid; A0A2Y9E0J2; -.
DR OrthoDB; 4724284at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; INTERLEUKIN-4; 1.
DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 3: Inferred from homology;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936,
KW ECO:0000256|PIRNR:PIRNR001941}; Cytokine {ECO:0000256|PIRNR:PIRNR001941};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001941-1};
KW Growth factor {ECO:0000256|PIRNR:PIRNR001941};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Secreted {ECO:0000256|PIRNR:PIRNR001941}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..139
FT /note="Interleukin-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016170314"
FT DISULFID 48..85
FT /evidence="ECO:0000256|PIRSR:PIRSR001941-1"
FT DISULFID 70..106
FT /evidence="ECO:0000256|PIRSR:PIRSR001941-1"
SQ SEQUENCE 139 AA; 15985 MW; D4A8F35366C7F003 CRC64;
MGLTFQLIPT LLCLLVCTSN FVHGQKCGIT LREIIKTLNF LTEKKHGCTE LTVADAFAAS
KNTTEKETIC RATTVLWQVY TRHKCFSKYL RGLRRSLSSM TNLTYCPVSE DRTSTLKDFL
ERLKTIMKEK YSKCGRRIF
//
