ID A0A2Y9E0Z4_TRIMA Unreviewed; 1138 AA.
AC A0A2Y9E0Z4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Folliculin-interacting protein 1 isoform X1 {ECO:0000313|RefSeq:XP_004384813.1};
GN Name=LOC101358868 {ECO:0000313|RefSeq:XP_004384813.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004384813.1};
RN [1] {ECO:0000313|RefSeq:XP_004384813.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
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DR RefSeq; XP_004384813.1; XM_004384756.3.
DR AlphaFoldDB; A0A2Y9E0Z4; -.
DR GeneID; 101358868; -.
DR OrthoDB; 2725349at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF12; FOLLICULIN-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 1.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 1.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 37..1129
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 92..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 127315 MW; 6CD57BFCD6E11BB4 CRC64;
MAPTLFQKLF SKRSGLCAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC ERRGRNVLFD
SSAKRKTEDI TVSKLCSDAQ VKVFGKCCQL KPGGDSSSSL DSSVTSSSDI KDQCPKYQGS
RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ IRSPPQLMLS KVFTARTGSS ICGSLNTLQD
SLEFINQDNN TLKADNNTVI NGLLGNIVHS NPMDMPGREL NEDRDSGIAR SASLSSLLIT
PFPSPNSSLT RSCASSYQRR WRRSQTTSLE NGVFPRWSIE ESFNLSDESC GPNPGIVRKK
KIAIGVIFSL SKDEDENSKF NEFFFSHFPL FESHMNKLKS AIEQAMKMSR RSTDASQRSL
AYNRIVDALN EFRTAICNLY TMPRIGEPVW LTMMSGTPEK NQLCYRFMKE FTFLMENAAK
NQFLPALITA VLTNHLAWVP TVMPNGQPPI KIFLEKHSSQ SVDMLAKTHP YNPLWAQLGD
LYGAIGSPVR LARTVIVGKR QDMVQRLLYF LTYFIRCSEL QETHLLENGE DEAIVMPGTV
ITTTLEKGEI EESEYVLITM HRNKSSLLFK EPEEARTSNC SCKYCSRPLL EQSIETVSQQ
DREDIQNISK KLLETSDECR MISPSDCREE NAFDTEQYRD KLRTCLDTKL ETVVCTGSAP
VDKRALSESG LEPAEETWQS EELLDSDNHM GKMMRSTGMI VEKKPPDKLV PAAFSCEAAQ
TKVTFLIGDS MSPDSDTELR SQAVVDQITR YHTKPLKEEG AAIDLHQETK KTTKDQSGES
GVQNMVSGEA CALPCWNHSD PESMSLFDEY FNDDSIETRT IDDIPVNTST DSKEHCCMLE
FSKRLCTKNS KENNGFCKCV ETIHQDACKT CFPQQDQRDT LSILVPHGDK ESSEKKVAVG
TEWDIPRNES SDSALGDSES EDTGHDTTRQ VSSYYGGEQE DWAEEDEIPF PGSKLIEVSS
VQPNIANFGR SLLGGYCSSY VPDFVLQGIG SDERLRQCLV SDLSHAVQHP VLDEPIAEAV
CIIADMDKWT VQVASSQRRM TDNKLGKEVL VSSLVSNLLH STLQLYKHNL SPNFCVMHLE
DRLQELYFKS KMLSEYLRGQ MRVHVKELGV VLGIESSDLP LLAAVASTHS PYVAQILL
//
