ID A0A2Y9E1C3_TRIMA Unreviewed; 234 AA.
AC A0A2Y9E1C3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Transcription factor HES-4 isoform X2 {ECO:0000313|RefSeq:XP_004384535.1};
GN Name=LOC101344152 {ECO:0000313|RefSeq:XP_004384535.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004384535.1};
RN [1] {ECO:0000313|RefSeq:XP_004384535.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_004384535.1; XM_004384478.2.
DR AlphaFoldDB; A0A2Y9E1C3; -.
DR GeneID; 101344152; -.
DR KEGG; tmu:101344152; -.
DR OrthoDB; 2907677at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11459; bHLH-O_HES1_4; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF136; TRANSCRIPTION FACTOR HES-4; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 34..91
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 110..143
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 234 AA; 24747 MW; 69100B422C4CABC4 CRC64;
MPAEPPGKPS ASPRAGAPAS ARRTPDKPRS AAEHRKSSKP VMEKRRRARI NESLAQLKTL
ILDALRKDSS RHSKLEKADI LEMTVRHLQG LRRVQVTAAL SADPAVLGKY RAGFNECLAE
VSRFLASCEG VPVDVRSRLL GHLASCLGQL ASSRRPAPPT PAAEAPASEV FTGCPLLPAF
DGPLPLLRPG AVFALLPAFS GSGPTAVPGL TGAPPAVPRP GPQGQAAPWR PWLR
//
