ID A0A2Y9E1R5_TRIMA Unreviewed; 749 AA.
AC A0A2Y9E1R5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Disks large homolog 2 isoform X8 {ECO:0000313|RefSeq:XP_004385561.1};
GN Name=LOC101352480 {ECO:0000313|RefSeq:XP_004385561.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004385561.1};
RN [1] {ECO:0000313|RefSeq:XP_004385561.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004385561.1; XM_004385504.2.
DR AlphaFoldDB; A0A2Y9E1R5; -.
DR GeneID; 101352480; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 47..134
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 142..229
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 318..399
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 433..503
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 559..734
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 749 AA; 83318 MW; 9A9E301C23E79656 CRC64;
MQRPSASRAE NYQLLWDTIA SLKQCEQAMQ HAFIPVNGTE IEYEFEEITL ERGNSGLGFS
IAGGTDNPHI GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNEVDVSEV SHSKAVEALK
EAGSIVRLYV RRRRPILETV VEIKLFKGPK GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG
AAQKDGRLQV GDRLLMVNNY SLEEVTHEEA VAILKNTSDV VYLKVGKPTT IYMTDPYGPP
DITHSYSPPM ENHLLSGNNG TLEYKTSLPP ISPGRYSPIP KHMLVEDDYT SHSQHSTAMR
QPSVTLQRAI SLEGEPRKVV LHKGSTGLGF NIVGGEDGEG IFVSFILAGG PADLSGELQR
GDQILSVNGI DLRGASHEQA AAALKGAGQT VTIIAQYQPE DYARFEAKIH DLREQMMNHS
MSSGSGSLRT NQKRSLYVRA MFDYDKSKDS GLPSQGLSFK YGDILHVINA SDDEWWQARR
VTLEGDSEEM GVIPSKRRVE RKERARLKTV KFNAKPGVID SKGDIPGLGD DGYGTKTLRG
QEDLILSYEP VTRQEINYTR PVIILGPMKD RINDDLISEF PDKFGSCVPH TTRPKRDYEV
DGRDYHFVIS REQMEKDIQE HKFIEAGQYN DNLYGTSVQS VRFVAERGKH CILDVSGNAI
KRLQVAQLYP IAIFIKPKSL EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG EYFTAIVQGD
TLEDIYTQCK LVIEEQSGPF IWIPSKEKL
//