ID A0A2Y9E1Y5_TRIMA Unreviewed; 699 AA.
AC A0A2Y9E1Y5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=ARF GTPase-activating protein GIT1 isoform X2 {ECO:0000313|RefSeq:XP_004385401.1};
GN Name=LOC101352305 {ECO:0000313|RefSeq:XP_004385401.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004385401.1};
RN [1] {ECO:0000313|RefSeq:XP_004385401.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004385401.1; XM_004385344.2.
DR AlphaFoldDB; A0A2Y9E1Y5; -.
DR GeneID; 101352305; -.
DR OrthoDB; 2877020at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF1; ARF GTPASE-ACTIVATING PROTEIN GIT1; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 104..136
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 202..232
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT DOMAIN 266..296
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT REGION 292..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 77642 MW; 1D88D2F40E713A91 CRC64;
MVHTLASNGA NSIWEHSLLD PAQVQSGRRK ANPQDKVHPI KSEFIRAKYQ MLAFVHKLPC
RDDDGVTAKD LSKQLHSSVR TGNLETCLRL LSLGAQANFF HPEKGTTPLH VAAKAGQTLQ
AELLVVYGAD PGSPDVNGRT PIDYARQAGH HELAERLVEC QYELTDRLAF YLCGRKPDHK
NGHYIIPQMA DSLDLSELAK AAKKKLQALS NRLFEELAMD VYDEVDRREN DAVWLATQNH
STLVTERSAV PFLPVNPEYS ATRNQGRQKL ARFNAREFAT LIIDILSEAK RRQQGKSLSS
PTDNLEFSTR SQSDLDDQHD YDSVASDEDT DQEPLRSAGA TRNNRARSID SSDLSDGAVT
LQEYLELKKA LATSEAKVQQ LMKVNSSLSD ELRRLQREIH KLQAENLQIR QQSGPVPTPP
IPSERAEHST VGPGGSAHRR DRQAFSMYEP GCALKPFGAP PGDELTTRLQ PFHSTELEDD
AIYSVHMPSG LYRIRKGVSA SAVPFAPSSP LLSCPQEGSR HPSKLSRHGS GADSDYENTQ
SGDPLLGLEG KRFLELGKEE DFHPELESLD EDLDPGLPST EDVILKTEQV TKNIQELLRA
AQEFKHDSFV PCSEKIHLAV TEMASLFPKR PALEPVRSSL RLLNASAYRL QSECRKTVPP
EPGAPVDFQL LTQQVIQCAY DIAKAAKQLV TITTREKKQ
//
