ID A0A2Y9E2Q5_TRIMA Unreviewed; 316 AA.
AC A0A2Y9E2Q5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=LOC101358618 {ECO:0000313|RefSeq:XP_004385971.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004385971.1};
RN [1] {ECO:0000313|RefSeq:XP_004385971.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_004385971.1; XM_004385914.2.
DR AlphaFoldDB; A0A2Y9E2Q5; -.
DR STRING; 127582.A0A2Y9E2Q5; -.
DR GeneID; 101358618; -.
DR KEGG; tmu:101358618; -.
DR InParanoid; A0A2Y9E2Q5; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF16; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..316
FT /note="Sulfotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016181787"
FT DOMAIN 64..303
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 73
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 73..77
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 156
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 164
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 264
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 279..283
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 265..274
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 316 AA; 36435 MW; F496CD62EAD423A0 CRC64;
MAVLLLGAVL LVAQPQVVPS RPTTVVTEPP GQPSQQELLR KVATLADDHL PDSAAPNGSA
RQLPQTIIIG VRKGGTRALL EMLSLHPDVA AAENEVHFFD WEEHYSHGLG WYLSQMPLSS
PHQLTVEKTP AYFTSPKVPA RVHSMNPAIR LLLILRDPSE RVLSDYTQVF YNHVQKRKPY
PSIEEVLVRD GRLNVDYKAL NRSLYHVHMQ NWLRFFPLHH IHIVDGDQLI RDPFPEIQKV
ERFLKLSPQI HPSNFYFNKT KGFYCLRDSG RDRCLHESKG RAHPHVDPKL LNKLHEYFHE
PNKKFFELVG RTFDWH
//
