ID A0A2Y9E4J4_TRIMA Unreviewed; 2112 AA.
AC A0A2Y9E4J4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Unconventional myosin-VIIb {ECO:0000313|RefSeq:XP_004387104.1};
GN Name=LOC101355135 {ECO:0000313|RefSeq:XP_004387104.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004387104.1};
RN [1] {ECO:0000313|RefSeq:XP_004387104.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_004387104.1; XM_004387047.2.
DR STRING; 127582.A0A2Y9E4J4; -.
DR GeneID; 101355135; -.
DR KEGG; tmu:101355135; -.
DR InParanoid; A0A2Y9E4J4; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 65..758
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 986..1189
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1194..1505
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1499..1565
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1640..1789
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1795..2112
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 635..657
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1585..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 158..165
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2112 AA; 241041 MW; 512B25EA1BDB5194 CRC64;
MATFRLGDHV WLDPPSANKT TVATGGIIKK TEPGKVLVED DEGKEHWIHA EDLGNLRPMH
PNSVLGVDDM IRLGDLNEAG VVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPIYTQEQVQ
LYYNHHVGEL PPHVFAIANG CYFNMRRNKR DQCCIISGES GAGKTETTKL ILQFLATISG
QHSWIEQQIL EANPILEAFG NAKTVHNDNS SRFGKYIDIY FNNTGVIEGA QIEQYLLEKS
RVCRQAPEER NYHIFYSMLM GMSAEEKKLL CLGMPSEYHY LTMGNCSSCE GLDDAKDYAH
IRSAMKILMF SDSENWDISK LLAAILHLGN VEFMATVFEN MDSSEVMEPS TFPIVMKLLE
VQHQALQDCL TKHSIIIRGE FVTRPLNIVQ AADRRDAFVK RIYGHLFLWV VKKINATIFS
PPSQDPKHVR RAIGLLDIFG FENFQSNSFE QLCINLANEH LQQFFVQHIF TMEQEEYRME
NIAWDYIHYT DNRHTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLKS VHANNKAFLQ
PKTIHDARFG IVHFAGEVYY KTEGFLEKNR DVLSTDILTL VHSSKNKFLK EIFKLEATET
KLGSGTIHLA RGQLFKSTEP TKQRSTLAGQ FKQSLDQLMK ILTSCQPYFI RCIKPNDYKK
PLLFNRELCL QQLRYSGMME TVQIRKLGFP IRYTFEEFSQ RFQVLLPSAV RVQLRHKFHQ
MTLRIADMWL GTDKDWKMGK TKIFLKDHQD TRLEIQRSQA LNTAALSIQK VLRGYKHRKE
FLRQKQAAVT LQANWRGFST RRNFKLILLG FERLQAIARS HLLARQYQTL REKIVHLQSR
CRGYLMRRAV QNRRKAVVII QAHARGMAAR QSFRRRKANG PLVIPAAQQS PSALPAKKPK
SIYDTITDTE MVEKVFGFLP SMIGGQEGQS APAFEDLETR TEQLPEVDLD TVPMAEEPEE
EADGLAEYTF PKFAATYFQK SASHTHIRRP LLYPLLYLED DNDCSAALAV WNIILRFMGD
LPEPVLFAKT SLRDSSVIQQ IHNTLGIQGS TQSPQPSGPG QVASQLSVKE KAFELDSPIS
DRPMSNLEKV HFIVAHAILR PSLRDEIYCQ ICKQLSENFK MSSLARGWIL LSLCLGCFPP
SERFMKYLLN FIGQGPAGYG PFCAKRLRRT YANGVRTEPP SWLELQAVKS KKHIPVHITM
VTGETLTITV DSASTAREVC LHIAHKQGLS DHLGFSLYVA VYNKFWSLGS GRDHVMDAVA
QCEQLARERG ESERQSPWRI YFRKEFFTPW HDSKEDPVST ELIYRQVLHG VWSSEYSFEK
EEELVELLAR HCYEQLGASA SSEAIQELLP SCIPAKLYRT KPPEKWASLV AAAHTKAPYT
QKQATVLAVR EQVVDMARLQ WPLLFSRLFE VTTLSGPRLP KTKLILAVNW KGLYFLDQRE
KVLLELSFPE VTGLVTNRAA QGGQRLTLST LHEEEYEFAT PSSVAIAELV AMFLEGLKER
SVFTMALQDR KATDDATLLT FKKGDLLILT KKQGLLASEN WTLGQNDRTG RTGLVPMACL
YIIPTVIKPS TPLLSLLAMS PEKRKLVAQE EGSTEPLPEE QPKEKPHTLE EFSYEFFRAP
EKETVSKAVF ARARGHLWAH SSEPLRQPLL KRVHANAELR DCACQTFMAI LKYMGDYPSR
QAWSSLELTD HIFSLAVQDV ALQDEVYCQI LKQLTHNSNR HSEERGWQLL WLCTGLFPPS
KALLPHAQKF VDTRRKKLLA PDCSRRLQRV LRAGPRKQPL HQVEVEAAEQ NITRICHKVY
FPNDTSKMLE VGANTRVRDV CQSIAAKLQL ASWEGCSLFV KIADKVFSQK EGDFFFDSLR
QVSDWVKKNK PQKEGAAVTL PYQVLFMRKL WLNVVPGKDV NADTILHYHQ ELPKYLRGFH
KCSREDAVHL AGLIYKAQFD NDRSQLASVP KILRQLVPEN LMRLMSSEEW KKNIPLAYDK
HVDKTVEEAK VAFLKWICRW PTFGSAFFEV KQTSEPSYPD IVLIAINRHG VLLIHPKTKE
LLTTYPFTKI ASWSSGSTYF HMVLGSLGRG SRLLCETSLG YKMDDLLTSY VQQLLSTVNK
QRSSRAPALA NL
//
