ID A0A2Y9E5V4_TRIMA Unreviewed; 477 AA.
AC A0A2Y9E5V4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Tripartite motif-containing protein 72 {ECO:0000256|ARBA:ARBA00014770};
DE AltName: Full=Mitsugumin-53 {ECO:0000256|ARBA:ARBA00030016};
GN Name=LOC101358348 {ECO:0000313|RefSeq:XP_004386755.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004386755.1};
RN [1] {ECO:0000313|RefSeq:XP_004386755.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}.
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DR RefSeq; XP_004386755.1; XM_004386698.1.
DR AlphaFoldDB; A0A2Y9E5V4; -.
DR STRING; 127582.A0A2Y9E5V4; -.
DR GeneID; 101358348; -.
DR KEGG; tmu:101358348; -.
DR InParanoid; A0A2Y9E5V4; -.
DR OrthoDB; 3453019at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd19797; Bbox2_TRIM72_C-IV; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF11; TRIPARTITE MOTIF-CONTAINING PROTEIN 72; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 14..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 81..122
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 271..475
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 144..171
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 477 AA; 52722 MW; 3BF4A4811FC73FAE CRC64;
MSATPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT
RPQALNTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL
PAAEAHARLK TQLPQQKMQL QEACMRKEKS VAVLEHQLAE VEETVRQFRG AVGEQLGKMR
VFLAALEASL DREAERVRDE AGVALRRELG GLNSYLEQLR QMEKVLEEVA DKPQTEFLTK
YCLVTSRLQK ILAESPPPAR LDIQLPVISD DFKFQVWRKM FRALMPALEE LTFDPSTAHP
SLVVSPSGRR VECSEQKAPP AGEDPRQFDK AVAVVAHQLL SDGEHYWEVE VGDKPRWALG
IIAAEASRRG RLHAVPSQGL WLLGLRDGKI LEAHVEAKEP RALRTPERRP TRIGLYLSFG
EGTLAFYDAT DADALVLLFA FHERLPGPVY PFFDVCWHDK GKNAQPLLLV GQDGGQA
//
