ID A0A2Y9E7K1_TRIMA Unreviewed; 270 AA.
AC A0A2Y9E7K1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transcription factor PU.1 isoform X2 {ECO:0000313|RefSeq:XP_004387757.1};
GN Name=LOC101352574 {ECO:0000313|RefSeq:XP_004387757.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004387757.1};
RN [1] {ECO:0000313|RefSeq:XP_004387757.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_004387757.1; XM_004387700.2.
DR AlphaFoldDB; A0A2Y9E7K1; -.
DR GeneID; 101352574; -.
DR KEGG; tmu:101352574; -.
DR OrthoDB; 3980839at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF16; TRANSCRIPTION FACTOR PU.1; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 170..253
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 123..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 31042 MW; D6FE21CB9E64351B CRC64;
MLQACKMEGF PLVPPPTEDL VPYDADLYQR PTHDYYQYLS SDGDSHSDHY WDFHPHHVHS
EFESFTENHF TELQSVQPPQ LQQLYRHMEL EQMHVLDTPM APPHASLGHQ VSYLPRMCVP
YPSLSPAQPS SDEEEGERHS PPLEVSDGEA DGLEPGPGLL HGETGSKKKI RLYQFLLDLL
RSGDMKDSIW WVDKDKGTFQ FSSKHKEALA HRWGIQKGNR KKMTYQKMAR ALRNYGKTGE
VKKVKKKLTY QFSGEVLGRG GLAERRHPPH
//
