ID A0A2Y9E8D2_TRIMA Unreviewed; 1487 AA.
AC A0A2Y9E8D2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_004389173.1};
GN Name=LOC101359073 {ECO:0000313|RefSeq:XP_004389173.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004389173.1};
RN [1] {ECO:0000313|RefSeq:XP_004389173.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR RefSeq; XP_004389173.1; XM_004389116.1.
DR STRING; 127582.A0A2Y9E8D2; -.
DR GeneID; 101359073; -.
DR KEGG; tmu:101359073; -.
DR InParanoid; A0A2Y9E8D2; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd14686; bZIP; 1.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT DOMAIN 745..938
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 65..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..669
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1192
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1250
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1379
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1487 AA; 162807 MW; 6E355CDF12409165 CRC64;
MEAGSATPGG TGSESPNRAV EYLLELNNII ESQQQLLETQ RRRIEELEGQ LDQLTQENRD
LREESQLHRG ELHRDPHSAR DSPGRESQYQ NLRETQFHHR ELRESQFHQA ARDVGYPNRD
GAYQNREAVY RDKERDASYP LQDSTYPPRE RDVAQCHLHH ENPALGRERG GREAGPAHSG
REKEAGYSAA VGVGSRPPRE RGQLSRGASR SSSPGAGGGH STSTSTSPAT TLQRKSDGEN
SRTVSVEGDA PGSDLSTAVD SPGSQPPYRL SQMPPTSSHM GGPPVGVGLP WAQRARLQPA
SVALRKQEEE EIKRSKALSD SYELSTDLQD KKVEMLERKY GGSFLSRRAA RTIQTAFRQY
RMNKNFERLR SSASESRMSR RIILSNMRMQ FSFEEYEKAQ NPAYFEGKPA SLDEGAMAGA
RSHRLERGLS YGGSCGGGID GGGSSVTTSG EFSNDITELE DSFSKQVKSL AESIDEALNC
HPSGPMSEEP GSAQLEKRES KEQQEDSSAT SFSDLPLYLD DPVPPPSPER LPSTEPPTQG
RPEFWAPAPL PPVPPPVQPG TREDGGREEG TRRGPGCLEC RDFRLRAAHL PLLTIEPPSD
SSVDLSDRSD RGSVHRQLVY EADGCSPHGT LKHKGPPGRA PIAHRHYPAP EGPAPAPPGP
LPPAPNSGTG PSGVPGGRRL GKCEAAGENS DGGDNESLES SSNSNETINC SSGSSSRDSL
REPPATGLCK QTYQRETRHS WDSPAFNNDV VQRRHYRIGL NLFNKKPEKG IQYLIERGFL
SDTPVGVAHF ILERKGLSRQ MIGEFLGNRQ KQFNRDVLDC VVDEMDFSSM DLDDALRKFQ
SHIRVQGEAQ KVERLIEAFS QRYCVCNPAL VRQFRNPDTI FILAFAIILL NTDMYSPSVK
AERKMKLDDF IKNLRGVDNG EDIPRDLLVG IYQRIQGREL RTNDDHVSQV QAVERMIVGK
KPVLSLPHRR LVCCCQLYEV PDPNRPQRLG LHQREVFLFN DLLVVTKIFQ KKKILVTYSF
RQSFPLVEMH MQLFQNSYYQ FGIKLLSAVP GGERKVLIIF NAPSLQDRLR FTSDLRESIA
EVQEMEKYRV ESELEKQKGM MRPNASQPGG AKDSVNGTLA RSSLEDTYGA GDGLKRGALS
SSLRDLSDAG KRGRRNSVGS LDSTIEGSVI SSPRPHQRMP PPPPPPPPEE YKSQRPVSNS
SSFLGSLFGS KRGKGPFQMP PPPTGQASAS SSSASSTHHH HHHHHHGHSH GGLGVLPNGQ
SKLQALHAQY CQGPGPAPPP YLPSQQPPLP PPPQQPPPLP QLGSIPPPPA SAPPVGPHRH
FHAHGPVPGP QHYTLGRPGR APRRGAGGHP QFAPHGRHPL HQPTSPLPLY SPAPQHPPTH
KQGPKHFIFS HHPQMMPAAG AAGGPGSRPP GGSYSHPHHP QSPLSPHSPI PPHPSYPPLP
PPSPHTPHSP LPPTSPHGPL HASGPPGTTN PPTANPKAKP SRISTVV
//
