ID A0A2Y9E8W7_TRIMA Unreviewed; 456 AA.
AC A0A2Y9E8W7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Ribonuclease inhibitor {ECO:0000256|ARBA:ARBA00014554};
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1 {ECO:0000256|ARBA:ARBA00032534};
GN Name=LOC101342553 {ECO:0000313|RefSeq:XP_004389428.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004389428.1};
RN [1] {ECO:0000313|RefSeq:XP_004389428.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis. {ECO:0000256|ARBA:ARBA00025561}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000256|ARBA:ARBA00011699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_004389428.1; XM_004389371.3.
DR AlphaFoldDB; A0A2Y9E8W7; -.
DR STRING; 127582.A0A2Y9E8W7; -.
DR GeneID; 101342553; -.
DR KEGG; tmu:101342553; -.
DR InParanoid; A0A2Y9E8W7; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 9.
DR Pfam; PF18779; LRR_RI_capping; 1.
DR SMART; SM00367; LRR_CC; 7.
DR SMART; SM00368; LRR_RI; 14.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480}.
SQ SEQUENCE 456 AA; 48983 MW; 52B025A25F428E4B CRC64;
MNLDIQCECL SDTQWKELLP QMQQVEVIRL DDCGLTEVRC EDISSALQAN PSLTELSLHN
SGLGDAGLRR LLQALQGPAR KIRKLSLQNC SLTAAGCTAL PGALRSLPSL LELHLSDNTL
DEAGLRLLCE GLRDPQCHLE RVHLEYCRLT AAGCEPLATA LRARPGLRGL VLSNNDLGED
GVRALCGGLL GARCPLETLR LASCGVTAAN CKDLCSLVAA KDSLQELDLG ENKLGDAGVA
TLCPGLLSPS SRLKTLWLWE CDISAEGCRE ISRVLHAKES LKELSLAGNE LGDQGARLLC
KALREPGCRL ESLWVKTCGL THACCPDFSA MLAQNKSLLE LQLSNNRLGD TGVQQLCQGL
GQPGATLQML CLGDCEVTDS GCTALASLLL SSRSLRELDL SNNCMGDPGV LQLVESLRQP
GCALRQLLLY DIYLSEAVDN HLKALEDSKP SLRIIS
//