ID A0A2Y9E917_TRIMA Unreviewed; 840 AA.
AC A0A2Y9E917;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Heat shock 70 kDa protein 4L {ECO:0000313|RefSeq:XP_004389336.1};
GN Name=LOC101350362 {ECO:0000313|RefSeq:XP_004389336.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004389336.1};
RN [1] {ECO:0000313|RefSeq:XP_004389336.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381}.
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DR RefSeq; XP_004389336.1; XM_004389279.2.
DR AlphaFoldDB; A0A2Y9E917; -.
DR STRING; 127582.A0A2Y9E917; -.
DR GeneID; 101350362; -.
DR KEGG; tmu:101350362; -.
DR InParanoid; A0A2Y9E917; -.
DR OrthoDB; 276440at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd11738; HSPA4L_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 2.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR042708; HSPA4L_NBD.
DR PANTHER; PTHR45639:SF5; HEAT SHOCK 70 KDA PROTEIN 4L; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Stress response {ECO:0000313|RefSeq:XP_004389336.1}.
FT REGION 531..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 94537 MW; FBF970618542C5A0 CRC64;
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN AAKSQIVTNV
RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSAG VKVRYLEEER PFAIEQVTGM
LLAKLKETSE NALKKPVADC VISIPSFFTD AERRSVMAAA QVAGLNCLRL MNETTAVALA
YGIYKQDLPP LDEKPRNVVF IDMGHSAYQV SVCAFNKGKL KVLATTFDPY LGGRNFDEAL
VDYFCDEFRT KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMSDLDVSSK
MNRAQFEQLC ASLLARVEPP LKAVMEEANL QREDISSIEI VGGATRIPAL KEQISKFFLK
DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLIPY SITLKWKTSF EDGTGECEVF
CKNHPAPFSK VITFHKKEPF ELEAFYTNPH EVPYPDPRIG SFTIQNVFPQ SDGDNSKVKV
KVRVNIHGIF SVASASVIEK QNLEGDHSDA PMETETSFKN ECKDDVDKMQ VDQEEGGHPK
CHAEHTPEEE IDHTGAKAKS ASSDKQERLN QTIKKGKVKS IDLPIQSSLC RQLGQDLLNS
YIENEGKMIM QDKLEKERND AKNAVEEHVY ELRDKLGAIY EKFITPEDLN KLSAILEDTE
NWLYEEGEDQ PKQVYVDKLQ ELKKYGQPIQ MRYMEHEERP KALNDLGKKI QLVMKVIEAY
RNKDERYDHL DPAEMEKVEK YISEAMNWLN NKMNAQNKLS LTQDPVVKVS EIVAKSKELD
NFCNPIIYKP KPEVEVAEDK AKANSEHNGP MDGQSGTDTN PDTTTDSSQR TKSSGEMEVD
//
