ID   A0A2Y9E9Y7_TRIMA        Unreviewed;       465 AA.
AC   A0A2Y9E9Y7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
GN   Name=LOC101344006 {ECO:0000313|RefSeq:XP_004389762.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004389762.1};
RN   [1] {ECO:0000313|RefSeq:XP_004389762.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR   RefSeq; XP_004389762.1; XM_004389705.1.
DR   AlphaFoldDB; A0A2Y9E9Y7; -.
DR   STRING; 127582.A0A2Y9E9Y7; -.
DR   GeneID; 101344006; -.
DR   KEGG; tmu:101344006; -.
DR   InParanoid; A0A2Y9E9Y7; -.
DR   OrthoDB; 5320180at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR016015; Clusterin_C.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00035; CLa; 1.
DR   SMART; SM00030; CLb; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..465
FT                   /note="Clusterin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016170322"
FT   DOMAIN          26..237
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   DOMAIN          238..459
FT                   /note="Clusterin C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00035"
FT   COILED          56..104
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   465 AA;  54229 MW;  C0046A576031FDCC CRC64;
     MKSPLWVFTV YLLWLKNCHC APTWKDKTTI GGNLKSSSES EEIEVDEEVK KALIGIKQMK
     IRMERREEEH TNLMETLKKC RAEKQEALKL MNEVQEHLEE EERLCQVSLT DSWDECRSCL
     ESNCMRYYTT CQPSWSSVKN TIEQFFMAIY QFLFPLHEDN ERDLPISEKL IEEDAHVAQI
     EDVFSRLTVD VASLFNRSWN VFKQMQQEFD QAFQSYFMSD TDLVEPHFFP ALSKEPMKKA
     DLLPSWDIPN FFQLFCNFSL SVYETVSKTI PGMLSAIEDL PKQNEDAHLG GVMSKILLVP
     NRGLCGQLSR NLTRCFKFHE RCQKCQDYLW RDCPGVPELH TELDEAFKLV NTSNQQYAQI
     LQMTQDHLED TTYLMEEMRK QFGWVSELEN QTLGTENTFS PVKVVPSVDE EKFSKQDETM
     IDLSILPSPN FTPKIPLEES AGSSNFIGYV VAKALQHFKE HFKPW
//