ID A0A2Y9EA61_TRIMA Unreviewed; 1038 AA.
AC A0A2Y9EA61;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protocadherin-10 isoform X2 {ECO:0000313|RefSeq:XP_004389317.1};
GN Name=LOC101344921 {ECO:0000313|RefSeq:XP_004389317.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004389317.1};
RN [1] {ECO:0000313|RefSeq:XP_004389317.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004389317.1; XM_004389260.3.
DR AlphaFoldDB; A0A2Y9EA61; -.
DR GeneID; 101344921; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF0; PROTOCADHERIN-10; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1038
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015916041"
FT TRANSMEM 712..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 123..248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 249..356
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 357..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..572
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 588..686
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 206..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 112840 MW; 03DA1A1C9BC8766C CRC64;
MIVLLFFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA RRFQTVPNSR
TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE NPLELFRVEI EVLDINDNPP
SFPEPDLTVE ISESATPGTR FPLESAFDPD VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF
AELVLEKPLD REQQAVHRYV LTAVDGGGGG EGGGGGGGGG GLPPQQQRTG TALLTIRVLD
SNDNVPAFDQ PVYTVSLPEN SPPGTLVIQL NATDPDEGQN GEVVYSFSSH ISPRARELFG
LSPRTGRLEV SGELDYEESP VYQVYVQAKD LGPNAVPAHC KVLVRVLDAN DNAPEISFST
VKEAVSEGAA PGTVVALFSV TDRDSEENGQ VQCELLGDVP FRLKSSFKNY YTIVTEAPLD
REAGDSYTLT VVARDRGEPA LSTSKSIQVQ VSDVNDNAPR FSQPVYDVYV TENNVPGAYI
YAVSATDRDE GANAQIAYSI LECQIQGMSV FTYVSINSEN GYLYALRSFD YEQLKDFSFQ
VEARDAGSPQ ALAGNATVNI LIVDQNDNAP AIVAPLPGRN GTPAREVLPR SAEPGYLLTR
VAAVDADDGE NARLTYSIVR GNEMNLFRMD WRTGELRTAR RVPAKRDPQR PYELVIEVRD
HGQPPLSSTA TLVVQLVDGA VEPPGGGGSG GGGSGEHQRP SRSGGGETSL DLTLILIIAL
GSVSFIFLLA MIVLAVRCQK EKKLNIYTCL ASDCCLCCCC CGGGGSTCCG RQARARKKKL
SKSDIMLVQS SNVPSNPAQV PVEESGGFGS HHHNQNYCYQ VCLTPESAKT DLMFLKPCSP
SRSTDTEHNP CGAIVTGYTD QQPDIISNGS ILSNETKHQR AELSYLVDRP RRVNSSAFQE
ADIVSSKDSG HGDSEQGDSD HDATNRGQSA GMDLFSNCTE ECKALGHSDR CWMPSFVPSD
GRQAADYRSN LHVPGMDSVP DTEVFETPEA QPGAERSFST FGKEKALHST LERKDLDGLL
SNTRAPYKPP YLTRKRIC
//
