ID A0A2Y9EAQ5_TRIMA Unreviewed; 318 AA.
AC A0A2Y9EAQ5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Death effector domain-containing protein {ECO:0000313|RefSeq:XP_004390231.1, ECO:0000313|RefSeq:XP_004390233.1};
GN Name=LOC101349768 {ECO:0000313|RefSeq:XP_004390231.1,
GN ECO:0000313|RefSeq:XP_004390233.1};
OS Trichechus manatus latirostris (Florida manatee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004390233.1};
RN [1] {ECO:0000313|RefSeq:XP_004390231.1, ECO:0000313|RefSeq:XP_004390233.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR RefSeq; XP_004390231.1; XM_004390174.2.
DR RefSeq; XP_004390232.1; XM_004390175.1.
DR RefSeq; XP_004390233.1; XM_004390176.2.
DR STRING; 127582.A0A2Y9EAQ5; -.
DR GeneID; 101349768; -.
DR KEGG; tmu:101349768; -.
DR OrthoDB; 3058503at2759; -.
DR Proteomes; UP000248480; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08790; DED_DEDD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR038856; DEDD/DEDD2.
DR InterPro; IPR049341; TRADD-like_N.
DR PANTHER; PTHR15205; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15205:SF2; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 1.
DR Pfam; PF20694; TRADD-like_N; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50168; DED; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 25..103
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT REGION 128..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36776 MW; CE1933CB567BF82C CRC64;
MAGLKRQASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL
IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE
TSIRYVTPRA LSDPEPRPPQ PPKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR
KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD
LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
YELGRQKLLR NLMLQALP
//
