ID   A0A2Y9EBE1_TRIMA        Unreviewed;       830 AA.
AC   A0A2Y9EBE1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 {ECO:0000313|RefSeq:XP_004390588.1};
GN   Name=LOC101350695 {ECO:0000313|RefSeq:XP_004390588.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004390588.1};
RN   [1] {ECO:0000313|RefSeq:XP_004390588.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_004390588.1; XM_004390531.3.
DR   AlphaFoldDB; A0A2Y9EBE1; -.
DR   GeneID; 101350695; -.
DR   OrthoDB; 5405363at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01178; IPT_NFAT; 1.
DR   CDD; cd07881; RHD-n_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF11; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480}.
FT   DOMAIN          331..512
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          716..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..161
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..239
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..760
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  88370 MW;  0E76C0932C14135D CRC64;
     MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GSAGAGAGRV LECPSIRITS ISPTPDPPAP
     LEDNPDAWGD SSSRDYPPPE GFGGYREAAG QGGGPFFSPS PGSSSLSSWS FFSDASDEAA
     LYAACDEVES ELNEAASRFG LGSPLPSPRS SPRPWTPEDP WNLYGPSPGG RGPEDGWLFL
     SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGPEPPPP PPLPFARDPG
     SPGPFDYAGA QPAESIPQKT RRTSSEQAVV SPRSEEPSPC NGKLPLGAEE AAAPPGGSRK
     EVASMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR IEVQPRAHHR
     AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA FYQVHRITGK
     MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV
     RLVFRVHVPQ GGGKVVSVQA ASAPIECSQR SAQELPQVEA YSPSACSMRG GEELVLTGSN
     FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR PVQVYFYVSN
     GRRKRSPTQS FKFLPVIFKE EPLPDSSFRG FPSPGPLFGT DMDFSPPRPL YPSYPHEDPA
     YETPYLSEGF SYGTPPLYPQ TGPPPSYRPG LRMFPDTGGT TGCARPPPVS FLPRPFPSDP
     YGGRGSPFPL GLPFPPPAPF RSPLPSSPSL EGPFPPQGGV HSPPAEGYNE VGPGYGPGEG
     APEQEKSKSG YSSGFRDSVP IQGITLEEVS EIIGRDLSGF PAHPGEEPPA
//