ID   A0A2Y9EC31_TRIMA        Unreviewed;       303 AA.
AC   A0A2Y9EC31;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN   Name=LOC101358803 {ECO:0000313|RefSeq:XP_004391406.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_004391406.1};
RN   [1] {ECO:0000313|RefSeq:XP_004391406.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC         bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC         ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC         Evidence={ECO:0000256|ARBA:ARBA00036007};
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC       {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR   RefSeq; XP_004391406.1; XM_004391349.1.
DR   STRING; 127582.A0A2Y9EC31; -.
DR   GeneID; 101358803; -.
DR   KEGG; tmu:101358803; -.
DR   InParanoid; A0A2Y9EC31; -.
DR   OrthoDB; 3083090at2759; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR11783:SF341; SULFOTRANSFERASE 6B1; 1.
DR   PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT   DOMAIN          56..285
FT                   /note="Sulfotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00685"
SQ   SEQUENCE   303 AA;  34699 MW;  AE49C46910809E8C CRC64;
     MADNSKFIDY IDEALEKSKE TALSRLLFTS QGIRYPVTMC TSETFQALDT FEARSDDIVL
     ASYPKCGSNW LLHIVSELIL AVSKKKYKYP EFPVLECGDP EKYQRMKQFP SPRILATHHH
     YDKLPGSIFK NNAXILVLFR NPKDTAVSFF HFHNDVPDIP SYGSWDEFFG QFMNGQVSWG
     RYFDFAINRN KHSDDANVKF MLYEDPKENL AFGVKEIAEF FGFSLTVEQI ETISAQSTFQ
     AMQARSQETH GAVGPFLFCK GEVGDWKNLF RETQSQEMDE KFKGCLTGTS LGAKLKYDSY
     CQA
//