ID A0A2Y9EDQ7_PHYMC Unreviewed; 392 AA.
AC A0A2Y9EDQ7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neutrophil cytosol factor 1 isoform X2 {ECO:0000313|RefSeq:XP_007100053.1};
GN Name=NCF1 {ECO:0000313|RefSeq:XP_007100053.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007100053.1};
RN [1] {ECO:0000313|RefSeq:XP_007100053.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007100053.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007100053.1; XM_007099991.4.
DR AlphaFoldDB; A0A2Y9EDQ7; -.
DR STRING; 9755.ENSPCTP00005009664; -.
DR GeneID; 102982542; -.
DR KEGG; pcad:102982542; -.
DR CTD; 653361; -.
DR InParanoid; A0A2Y9EDQ7; -.
DR OrthoDB; 2910367at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR CDD; cd06887; PX_p47phox; 1.
DR CDD; cd12021; SH3_p47phox_1; 1.
DR CDD; cd12022; SH3_p47phox_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR015039; NCF1_C.
DR InterPro; IPR032136; NCF1_PBR/AIR.
DR InterPro; IPR035756; NCF1_SH3_1.
DR InterPro; IPR035757; NCF1_SH3_2.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034909; PX_p47phox.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF6; NEUTROPHIL CYTOSOL FACTOR 1-RELATED; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF16621; NCF1_PBR_AIR; 1.
DR Pfam; PF08944; p47_phox_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00498; P47PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..125
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 156..215
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 226..285
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 283..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 45104 MW; 5A568825800AEBBD CRC64;
MGDPFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRRFTEIYEF HKILKEMFPI
EAGDINPEKR IIPHLPAPRW FDGQRVAESR QGTLTEYCNS LMNLPGKISR CNHLLNFFKV
RPDDLKLPTD SQVKKPETYL VPRDGKSNVT DITGPIILQT YRAIADYEKS SGSEMALATG
DVVDVVEKSQ SGWWFCQMKT KRGWVPASYL EPLDSPDEAE DPEPNYAGEP YVTIKAYTAL
LEDEMSLEQG ETIEVIHKLL DGWWVIRKED VTGYFPSMYL QQAGQDTDQA QSRIKRGAPP
RRSSIRNAHS IHQQSRKRLS QDTYRRNSVR FLQQRRPRAR PGPQSPGSPL KEEEPPKTER
PKPQPAVPPR PSADLILHRC SESTKRKLAS AV
//
