ID A0A2Y9EEX9_PHYMC Unreviewed; 247 AA.
AC A0A2Y9EEX9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Stanniocalcin-1 {ECO:0000256|RuleBase:RU369112};
DE Short=STC-1 {ECO:0000256|RuleBase:RU369112};
GN Name=STC1 {ECO:0000313|RefSeq:XP_007100611.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007100611.1};
RN [1] {ECO:0000313|RefSeq:XP_007100611.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007100611.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Stimulates renal phosphate reabsorption, and could therefore
CC prevent hypercalcemia. {ECO:0000256|RuleBase:RU369112}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family.
CC {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR RefSeq; XP_007100611.1; XM_007100549.3.
DR AlphaFoldDB; A0A2Y9EEX9; -.
DR STRING; 9755.ENSPCTP00005000689; -.
DR Ensembl; ENSPCTT00005000772; ENSPCTP00005000689; ENSPCTG00005000557.
DR GeneID; 102984911; -.
DR KEGG; pcad:102984911; -.
DR CTD; 6781; -.
DR InParanoid; A0A2Y9EEX9; -.
DR OrthoDB; 4573585at2759; -.
DR Proteomes; UP000248484; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0035988; P:chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0001886; P:endothelial cell morphogenesis; IEA:Ensembl.
DR GO; GO:0003421; P:growth plate cartilage axis specification; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:1903403; P:negative regulation of renal phosphate excretion; IEA:Ensembl.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
DR GO; GO:0044070; P:regulation of monoatomic anion transport; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF1; STANNIOCALCIN-1; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU369112};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369112};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..247
FT /note="Stanniocalcin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016110877"
SQ SEQUENCE 247 AA; 27476 MW; B4F94A319320B97B CRC64;
MLQNSAVLLV LVISASATHE AEQNDSVSPR KARVAAQNSA EVVRCLNSAL QVGCGAFACL
ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGVTSKVFLA IRRCSTFQRM
IAEVQEECYS KLNVCSVAKR NPEAITEVVQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD
SLMEKIGPNM ASLFHILQTD HCAHTHQRAD FNRRRANEPQ KLKVLLRSLR GEVASPSLIK
RTSHESA
//
