ID   A0A2Y9EGG4_PHYMC        Unreviewed;       327 AA.
AC   A0A2Y9EGG4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=DNA-binding death effector domain-containing protein 2 isoform X17 {ECO:0000313|RefSeq:XP_007102243.2};
GN   Name=LOC102986691 {ECO:0000313|RefSeq:XP_007102243.2};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007102243.2};
RN   [1] {ECO:0000313|RefSeq:XP_007102243.2}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007102243.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
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DR   RefSeq; XP_007102243.2; XM_007102181.4.
DR   AlphaFoldDB; A0A2Y9EGG4; -.
DR   STRING; 9755.ENSPCTP00005008728; -.
DR   Ensembl; ENSPCTT00005009616; ENSPCTP00005008728; ENSPCTG00005006152.
DR   Proteomes; UP000248484; Chromosome 17.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030262; P:apoptotic nuclear changes; IEA:Ensembl.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR038856; DEDD/DEDD2.
DR   InterPro; IPR049341; TRADD-like_N.
DR   PANTHER; PTHR15205; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15205:SF1; DNA-BINDING DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01335; DED; 1.
DR   Pfam; PF20694; TRADD-like_N; 1.
DR   SMART; SM00031; DED; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50168; DED; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125,
KW   ECO:0000313|RefSeq:XP_007102243.2};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          25..104
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   REGION          107..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36189 MW;  EE5F1E195C6B133D CRC64;
     MALSGSTPAP SWEEDECLDY YGMLSLHRVF EVVGGQLSEC ELELLAFLLD EVPGAAGGLA
     RARSGLELLL ELERRGQCDE SNLRLLGQLL RVLSRHDLLP HLARKRRWPV SPERSSYGTS
     SSSSKRKEGG CRRSQQSRSS SDAEQSQWET GSPPTKRQRR SRGRPSGGAR RRQRGSPATP
     QQQQEPAGPT SEGKVTCDIR LRVRAEYCEH GPALEQGVAS RRPQALARQL DVFGQATAVL
     RSRDLGSVVC DIKFSELSYL DAFWGDYLSG ALLQALRGVF LTEALREAVG REAVRLLVSV
     DEADYEAGRR RLLLMEEEGG RRLPEAS
//