ID   A0A2Y9EHH6_PHYMC        Unreviewed;       652 AA.
AC   A0A2Y9EHH6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Endoglin isoform X1 {ECO:0000313|RefSeq:XP_007101842.1};
GN   Name=ENG {ECO:0000313|RefSeq:XP_007101842.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007101842.1};
RN   [1] {ECO:0000313|RefSeq:XP_007101842.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007101842.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007101842.1; XM_007101780.4.
DR   AlphaFoldDB; A0A2Y9EHH6; -.
DR   STRING; 9755.ENSPCTP00005011930; -.
DR   GeneID; 102988385; -.
DR   KEGG; pcad:102988385; -.
DR   CTD; 2022; -.
DR   InParanoid; A0A2Y9EHH6; -.
DR   OrthoDB; 5320235at2759; -.
DR   Proteomes; UP000248484; Chromosome 9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR14002:SF1; ENDOGLIN; 1.
DR   PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR   Pfam; PF00100; Zona_pellucida; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..652
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015926182"
FT   TRANSMEM        581..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          362..531
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|Pfam:PF00100"
FT   REGION          624..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..652
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  70594 MW;  638FBB45098D3FE2 CRC64;
     MDRGMFPQAV ALLLALCSLG PTSLAETVYC DLQPVDPQVT YITSQVSEGC VAQSPNATLE
     VHILFLEFLK EVSSLELTLQ TSKQNGTLPR EVLLILSTNK TIFLKLQAPG IPLHLAYNPR
     LVVFQETTEV NTTQLPPFTT RGELLNWADT KGPITSAAEL NNPQSILLRL DQAPRSPSSC
     SLEPHKDMGH TLEWSPNAQA SVRGCRLEGV AGHKEAHILR VLPGPEAWPR TVTVKVELSC
     ASRDPDAAVL ILQGPPYVSW LIDANHNMQI WTTGEYSFKI FPEKNIRGFH LPNTTQGLLG
     EARRLNASVV ASFVELPLAS VVSLRAPSCG SGLQPSPTPV QTTPPKEGCN QELLLSLIQP
     KCSEDVMTLV LNKDLISTLR CTITSLTFWD SSCQAEDRDD QFVLRSGYSS CGMIVTENVI
     SNEVIVNLLS SSSPQQKKVQ CINMDSLSFQ LGLYLSPHFL QASNTIELGQ QGFVQVSVSP
     SIPELTIQLD SCQLNLGPDM EIVELIQSQA AKSSCVSLLS PSPGGDMRFS FLLRGYMVPM
     PTTSILSCTV ALRLSTWSLD VQRTVSTRLN VVSPGLHDKG LVLPAVLGIT FGAFLIGALL
     TAALWYIYLH TRHPGKREPV VAVAAPASSE SGSTNHSIGS TQSTPCSTSS MA
//