ID   A0A2Y9EHP5_PHYMC        Unreviewed;       861 AA.
AC   A0A2Y9EHP5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Dimethylglycine dehydrogenase, mitochondrial {ECO:0000313|RefSeq:XP_007103023.2};
GN   Name=DMGDH {ECO:0000313|RefSeq:XP_007103023.2};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007103023.2};
RN   [1] {ECO:0000313|RefSeq:XP_007103023.2}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007103023.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   RefSeq; XP_007103023.2; XM_007102961.2.
DR   AlphaFoldDB; A0A2Y9EHP5; -.
DR   STRING; 9755.ENSPCTP00005005507; -.
DR   Ensembl; ENSPCTT00005006055; ENSPCTP00005005507; ENSPCTG00005003853.
DR   KEGG; pcad:102991899; -.
DR   InParanoid; A0A2Y9EHP5; -.
DR   OrthoDB; 1815533at2759; -.
DR   Proteomes; UP000248484; Chromosome 8.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0047865; F:dimethylglycine dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0042426; P:choline catabolic process; IEA:Ensembl.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          47..409
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          412..465
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          474..739
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          765..843
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   861 AA;  96231 MW;  AE402DABB9022AF5 CRC64;
     MFRPGALRLR GFPLRGSPGR LRSVCGREGE ENPPLPAETR WKDRAETVII GGGCVGVSLA
     YHLAKAGMKD VVLLEKSELT AGSTWHAAGL TTYFHPGINL KKIHYDSIKL YEKLEEETGQ
     VVGFHQPGSI RIATTPVRVD EFKYQMTRAG WHATEQYIIE PEKIQEMFPL LNMNKILAGL
     YNPGDGHIDP YSLTMALAAG ARKYGALLKY PAPVTSLKPR SDGTWDVETP QGSMRANRIV
     NAAGFWAREV GKMIGLEHPL IPVQHQYVVT STIPEVKALK RELPVLRDLE GSYYLRQERD
     GLLFGPYESQ EKMKVQDSWV TSGVPPGFGK ELFESDLDRI MEHVEAAMEM VPVLKKADII
     NIVNGPITYS PDILPMVGPH QGVRNYWVAI GFGYGIIHAG GVGKYLSDWI LHGEPPFDLI
     ELDPNRYGKW TTTQYTEAKA RESYGFNNIV GYPKEERFAG RPTQRVSGLY ETLESKCSMG
     FHAGWEQPHW FYQPGQDTGY RPSFRRTNWF DPVGSEYKQV MQRVGVIDLS PFGKFNIKGQ
     DSIRLLDHLF ANVIPKVGFT NISHMLTPKG QVYAELTVSH QSPGEFLLIT GSGSELHDLR
     WIEEEAVKGG YDVEIKNITD ELGVLGVAGP HARKVLQKLT SEDLSDDVFK FLQTKSLKVS
     NIPVSAIRIS YTGELGWELY HRREDSAALY DIIMNAGQKE GIDNFGTYAM NALRLEKAFR
     AWGSEMNCDT NPLEAGLGYF VKLNKPADFI GKQALKQIKA KGLKRRLVCL TLATDDVDPE
     GNESIWYDDK VVGNTTSGSY SYSIQKSLAF AYVPVELSKV GQEVEVELLG KNYSATVIQE
     PLVLTEPIRN QLQKKGGKDK I
//