ID   A0A2Y9EHS5_PHYMC        Unreviewed;       878 AA.
AC   A0A2Y9EHS5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial {ECO:0000313|RefSeq:XP_007102635.2, ECO:0000313|RefSeq:XP_007102636.2};
GN   Name=PDPR {ECO:0000313|RefSeq:XP_007102635.2,
GN   ECO:0000313|RefSeq:XP_007102636.2, ECO:0000313|RefSeq:XP_007102637.2,
GN   ECO:0000313|RefSeq:XP_023980621.1, ECO:0000313|RefSeq:XP_054934842.1,
GN   ECO:0000313|RefSeq:XP_054934843.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007102635.2};
RN   [1] {ECO:0000313|RefSeq:XP_007102635.2, ECO:0000313|RefSeq:XP_007102636.2}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007102635.2,
RC   ECO:0000313|RefSeq:XP_007102636.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   RefSeq; XP_007102635.2; XM_007102573.4.
DR   RefSeq; XP_007102636.2; XM_007102574.4.
DR   RefSeq; XP_007102637.2; XM_007102575.4.
DR   RefSeq; XP_023980621.1; XM_024124853.3.
DR   RefSeq; XP_054934842.1; XM_055078867.1.
DR   RefSeq; XP_054934843.1; XM_055078868.1.
DR   STRING; 9755.ENSPCTP00005016248; -.
DR   KEGG; pcad:102990415; -.
DR   OrthoDB; 1815533at2759; -.
DR   Proteomes; UP000248484; Chromosome 17.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|RefSeq:XP_007102635.2,
KW   ECO:0000313|RefSeq:XP_007102636.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          44..87
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
SQ   SEQUENCE   878 AA;  99435 MW;  D6039E7F110B5FCB CRC64;
     MFYRLLSVVR RPRSSQGWQK WSSARSGASA AKAHSVALPA QAQVVICGGG IMGTSVAYHL
     SKMGWKDIVL LEQGRLAAGS TRFCAGILST ARHLTIEQKM ADYSNKLYHQ LEQETGIHTG
     YIRTGSIFLA QTQDRLISLK RINSRLNVIG IPSEIISPKK VAELHPLLNV HDLVGAMHVP
     EDAVVSSADV ALALASAASQ NGVQIYDRTS ILHVMVRKGQ VTGVETDKGQ IQCHYFVNCA
     GQWAYELGLS NEEPVSIPLH ACEHFYLLTR PWETPLQSNA PTIVDADGRI YIRNWQGGIL
     SGGFEKNPKP IFTEGKNQLE IQNLQEDWDH FEPLLSSLLR RMPELETLEI MKLVNCPETF
     TPDMRCIMGE SPSVRGYFVL VGMNSAGLSF GGGAGRYLAE WMVHGYPSES VWELDLKRFG
     ALQSSRTFLR HRVMEVMPLL YDLKVPRWDF QTGRQLRTSP LYDRLDAQGA RWMEKHGFER
     PKYFVPPDKD LLALEQSKTF YKPDWFEIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDQA
     LEILQYLFSN DLDVPVGHIV HTGMLNEGGG YENDCSIARL SKRSFFMISP TDQQVHCWAW
     LKKYMPEDSN LILEDVTWKY TALNLIGPRA VDVLSELSYA PMTPDHFPSL FCKEMSVGYA
     NGIRVMSMTH TGEPGFMLYI PIEYALHVYN EVMSVGQKYG IRNAGYYALR SLRIEKFFAF
     WGQDLNTLTT PLECGRESRV KLDKGMDFIG RDALLQQKQN GVYKRLTMFI LDDHDTDLDL
     WPWWGEPIYR NGQYVGKTTS SAYGYTLERH VCLGFVHNFS EDTGEEQVVT ADFINRGEYE
     IDIAGHRFQA KAKLYPVTSL FTHKRRKDDV ELSDLHGK
//