ID A0A2Y9EPZ2_PHYMC Unreviewed; 493 AA.
AC A0A2Y9EPZ2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Amphoterin-induced protein 1 {ECO:0000313|RefSeq:XP_007106534.1, ECO:0000313|RefSeq:XP_028341346.1};
GN Name=AMIGO1 {ECO:0000313|RefSeq:XP_007106534.1,
GN ECO:0000313|RefSeq:XP_028341346.1, ECO:0000313|RefSeq:XP_028341347.1,
GN ECO:0000313|RefSeq:XP_054938969.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028341347.1};
RN [1] {ECO:0000313|RefSeq:XP_007106534.1, ECO:0000313|RefSeq:XP_028341346.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007106534.1,
RC ECO:0000313|RefSeq:XP_028341346.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. AMIGO family.
CC {ECO:0000256|ARBA:ARBA00005670}.
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DR RefSeq; XP_007106534.1; XM_007106472.2.
DR RefSeq; XP_007106535.1; XM_007106473.1.
DR RefSeq; XP_028341346.1; XM_028485545.2.
DR RefSeq; XP_028341347.1; XM_028485546.2.
DR RefSeq; XP_054938969.1; XM_055082994.1.
DR STRING; 9755.ENSPCTP00005025346; -.
DR Ensembl; ENSPCTT00005027910; ENSPCTP00005025346; ENSPCTG00005018151.
DR GeneID; 102995986; -.
DR KEGG; pcad:102995986; -.
DR CTD; 57463; -.
DR OrthoDB; 3472064at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR031283; AMIGO.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24368; AMPHOTERIN-INDUCED PROTEIN; 1.
DR PANTHER; PTHR24368:SF1; AMPHOTERIN-INDUCED PROTEIN 1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..493
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069056"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 283..353
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 405..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55382 MW; 7CDB4BE97914B9F9 CRC64;
MQPQRDLRGL WLLLLSLFLL LFEEARAGRP LVSCPAACLC ASNILSCSKQ QLPNVPHSLP
SYTALLDLSH NNLSRLRAEW TPTRLTHLHS LLLSHNQLNF ISSEAFSPVP NLRYLDLSSN
QLRTLDEFLF SELQALEVLL LYNNHIMAVD RCAFDDVVQL QKLYLSQNQI SRFPLELVKE
GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLHCDCELY QLFSHWQYRQ
LSSVMDFQED LYCMSSKKLH NVFSLSFLNC SEYKERAWEA HLGDTLTIKC DTKQQGMTKV
WVTPSNERVL DEVANSTVTV SKDGSLHFRR VQVEDGGVYT CYAVGEAFNE TLSVELKVYN
FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS
TTPNHDPMAG GDKDDGFDQR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE
SVSSVFSDTP IVV
//
